Structure and Physiology

Jentsch TJ, Stein V, Weinreich F et al (2002) Molecular structure and physiological function of chloride channels. Physiol Rev 82 503—568... 

Desiccation tolerance and injury avoidance The remarkable tolerance to prolonged anhydrobiosis in resurrection plants suggests they are able to maintain essential structure and physiological integrity in the dry state or are able to repair dehydration-induced damage rapidly following rehydration. 

Peakall, D.B., Lincer, J.L., and Risebrough, R.W. et al. (1973). DDE-induced eggshell thinning structural and physiological effects in three species. Comparative and General Pharmacology 4, 305-313. 

Despite its widespread use in therapy as an anticoagulant and antilipe-mic agent, several aspects of the structure and physiological function of heparin remain obscure. However, active reseach has now contributed to a better understanding of the molecular basis for the pharmacological activity of this polysaccharide. 

In order to answer questions regarding the therapeutic and cosmetic uses of the myriad dermatological concoctions available, a pharmacist must be knowledgeable about the anatomical structure and physiological functions of the skin and the chemical compositions and physicochemical properties of its constituent tissues. Some understanding of how its properties are affected by disease and damage is a must, as is... 

Whiteley AS, Bailey MJ (2000) Bacterial community structure and physiological state within an industrial phenol bioremediation system. Appl Environ Microbiol 66 2400-2407... 

Hesse s second source, Die Arzneimittel Synthese by Sigmund Frankel, was a largely theoretical work by a prominent scientist. Frankel tried to establish direct and specific relationships between chemical structure and physiological activity. In this book Hesse found broad assertions, such as the statement that all unsulfonated azo dyes were harmful, as well as specific claims. Although it was perhaps natural that, as an organic chemist,... 

Structure and physiology of the kidney glomerular filtration tubular activity selective reabsorption and secretion, often using specific carrier mechanisms carbonic anhydrase and acid-base balance. The kidney also produces, and is sensitive to, hormones actions of the hormones ADH, aldosterone and PTH the kidney as a secretory organ erythropoietin, the renin-angiotensin system vitamin D3. 

Blackman, G.E., Parke, M.H., and Carton, G. The physiological activity of substituted phenols. 1. Relationships between chemical structure and physiological activity, Arch. Biochem. Biophys., 54(1) 55-71,1955. 

One of the great unifying features of life is the similarity in metabolic patterns. As diverse as life forms are, their patterns of metabolic activity— how molecules are formed and degraded—are remarkably closely related. That is not to say that they are identical. They are not. Indeed, identity in metabolic pattern would imply identity in structure and physiology, which is certainly not the case. Nonetheless, the similarities are striking. Variations on a unified central metabolic theme give rise to the diversity of life forms. Nowhere is this fundamental fact more clearly evident than in the central metabolic pathway known as the citric acid cycle. 

In the following sections tumour cell-directed targeting and intracellular delivery of drugs will be discussed. This includes crucial factors such as tumour structure and physiology as well as physiological, cellular, molecular, biochemical and pharmacokinetic barriers. 

It is with great pleasure that we accepted the offer by CRC Press to assemble and edit this compilation of reviews on flavonoids and their properties and functions for the present volume. We considered the volume timely in that the last book of this general type, The Flavonoids — Advances in Research Since 1986 (edited by Jeffrey B. Harborne), appeared over a decade ago. Since then, advances in the flavonoid field have been nothing short of spectacular. These advances are particularly evident in the contributed chapters that cover the discovery of a variety of new flavonoids the application of advanced analytical techniques genetic manipulation of the flavonoid pathway improved understanding of flavonoid structures and physiological functions in plants and animals and, perhaps most importantly, the significance of flavonoids to human health. 

This iron storage protein is widely distributed in many mammalian cells, and also in invertebrates, plants, fungi and a number of bacteria, where it is associated with a fe-type cytochrome. There have been considerable advances recently in the understanding of its structure and physiological function.1093 1098... 

Hantgan, R. R., Simpson-Haidaris, P. J., Francis, C. W., and Marder, V. J. (2000). Fibrinogen structure and physiology. In Hemostasis and Thrombosis Basic Principles and Clinical Practice (R. W. Colman, J. Hirsh, V. J. Marder, A. W. Clowes, andj. N. George, Eds.), pp. 203-232. Lippincott, Williams Wilkins, Philadelphia. 

---