Structural strain specificity

Diaz-Avalos, R., King, C. Y., Wall,J., Simon, M., and Caspar, D. L. (2005). Strain-specific morphologies of yeast prion amyloid fibrils. Proc. Natl. Acad. Sci. USA 102,10165-10170. Donne, D. G., Viles, J. H., Groth, D., Mehlhom, I., James, T. L., Cohen, F. E., Prusiner, S. B., Wright, P. E., and Dyson, H.J. (1997). Structure of the recombinant full-length hamster prion protein PrP(29-231) The N terminus is highly flexible. Proc. Natl. Acad. Sci. USA 94, 13452-13457. 

L-glycero-mannoheptose. The polysaccharide component of LPS may be divided into several structural domains. The inner (core) domains vary relatively little between LPS molecules isolated from different Gram-negative bacteria. The outer (O-specific) domain is usually bacterial strain-specific. 

B. L. Reuhs, D. P. Geller, J. S. Kim, J. E. Fox, V. S. Kumar Kolli, and S. G. Pueppke, Sinorhizobium fredii and Sinorhizobium meliloti produce structurally conserved lipopolysaccha-rides and strain-specific K antigens, Appl. Environ. Microbiol., 64 (1998) 4930 1938. 

There are many other kinds of reactive intermediates, which do not fit into the previous classifications. Some are simply compounds that are unstable for various possible reasons, such as structural strain or an unusual oxidation state, and are discussed in Chapter 7. This book is concerned with the chemistry of carbocations, carbanions, radicals, carbenes, nitrenes (the nitrogen analogs of carbenes), and miscellaneous intermediates such as arynes, ortho-quinone methides, zwitterions and dipoles, anti-aromatic systems, and tetrahedral intermediates. This is not the place to describe in detail the experimental basis on which the involvement of reactive intermediates in specific reactions has been estabhshed but it is appropriate to mention briefly the sort of evidence that has been found useful in this respect. Transition states have no real hfetime, and there are no physical techniques by which they can be directly characterized. Probably one of the most direct ways in which reactive intermediates can be inferred in a particular reaction is by a kinetic study. Trapping the intermediate with an appropriate reagent can also be very valuable, particularly if it can be shown that the same products are produced in the same ratios when the same postulated intermediate is formed from different precursors. 

The compliance is the ability of one native soft tissue to adapt its volume unda pressure variations. Regarding fiber and yam interlacing patterns, fibrous structures have specific stress—strain behavior with initial debulking at low-load level and flien strengthening of more aligned fibers at higher-load level. Stress—strain curve patterns of fibrous tissue are similar to those of soft tissue, which is encouraging to mimic ECM. 

More detailed analyses of the genomic datasets that became available recently confirmed the existence of strain-specific ORFs heterozygosity (single nucleotide variants ranging from 1000 to 1900 heterozygous loci per strain) and large-scale structural variations (e.g. whole-chromosome aneuploidies and interspecific hybrids). 

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