Structural logic’s rule

C. Rule number three the structural logic s rule... 

The end user of the results of the study is an additional factor to consider. In drug development programs recommendations for structural modification should be logical and easy to implement by medicinal chemists involved in designing the next sequence of compounds. Lipinski s rule of 5 (Lipinski et al., 1997) has no doubt found such wide application in industry, because the rule can be so easily interpreted and applied to new compounds. The paper by Lipinski (2000) shows a simple graph distributed to chemists that can be used to determine whether the solubility of a... 

Let s address the question now as it equally applies to the 8- and 18-electron rules. Compounds that follow the rules are classified as normal and define the electronic accounting favored when no other factors are of overriding importance. The rules give the experimental chemist a simple method to rationalize and predict compound stoichiometry and connectivity. The rules permit logical categorization of the myriad of compounds via similarities in an electron count. Both facilitate more rapid development of a field such as cluster chemistry where both structure and composition can seem intimidating in the absence of an organizing principle. 

The back-to-nature ethic embodied in both Russian ideals about the organic life and dachniki s activities contributes an important comparative example to understandings of environmental and nature movements in other parts of the world. Russians ideas about environmental stewardship invert the expected relationship between person and land, so that nature is understood to care for and protect people. Yet this does not absolve individuals from responsible behavior, even though what constitutes responsible action might seem at odds with the goals of environmental conservation. As a result, while popular opinion in Russia might hold that litter and fires in forests are undesirable, the perpetuation of such practices is understandable within the logic of a philosophy that sees nature as the one space where the normal rules and structures do not apply. 

With the help of experts, the proliferation critical path is being formulated as logically connected if-then rules. The primary purpose of this formulation is to recognise and place information (e.g., export data) in the appropriate place(s) in the critical path structure. The critical path takes into account the possibility of shortening any of the paths to weaponisation at each of the fuel-cycle steps through external procurement (e.g., procurement of source material, UF, enriched uranium, etc.) and technical assistance. Nuclear activity profile for a given country is then obtained from a model presented in Fig. 11.8. 

The logical approach was u,sed for creating computer systems for the structural interpretation of the IR spectrum, the T(A, 2) function being presented by the system s knowledge base. A description of the systems based on logical rules can be found in reviews and the original publications. 5 ... 

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