Structural genomics programs

Norvell, J.C., Machalek, A.Z., Structural genomics programs at the US National Institute of General Medical Sciences. Nat. Struct. Biol. 2000, 7, 931. 

The term "structural genomics" is used to describe how the primary sequence of amino acids in a protein relates to the function of that protein. Currently, the core of structural genomics is protein structure determination, primarily by X-ray crystallography, and the design of computer programs to predict protein fold structures for new proteins based on their amino acid sequences and structural principles derived from those proteins whose 3-dimensional structures have been determined. Plant natural product pathways are a unique source of information for the structural biologist in view of the almost endless catalytic diversity encountered in the various pathway enzymes, but based on a finite number of reaction types. Plants are combinatorial chemists par excellence, and understanding the principles that relate enzyme structure to function will open up unlimited possibilities for the... 

Burset, M. Guigo, R. (1996). Evaluation of gene structure prediction programs. Genomics 34, 353-67. 

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