Stress-related mucosal damage

Stress-Related Mucosal Damage Prophylaxis Protocol... 

Convincing evidence on the efficacy of enteral nutrition in the prevention of stress-related mucosal damage not... 

Gl, gastrointestinal H. pylori, Helicobacter pylori NSAID, non-steroidal anti-inflammatory drug SRMD, stress-related mucosal damage. 

Stress-related mucosal damage occurs most frequently in critically ill patients and is thought to be caused by factors such as compromised mesenteric perfusion rather than HP or NSAIDs. Its onset is usually acute, and in a small proportion of patients may progress to deep ulceration and hemorrhage. 

Intravenous histamine-2-receptor antagonists such as ranitidine, famotidine, and cimetidine are compatible with PN and can be added to the daily PN for prevention of stress-related mucosal damage and peptic ulcer disease. This provides a continuous acid suppression and reduces nursing time by avoiding intermittent scheduled infusions. 

Peptic ulcer disease (PUD) refers to a group of ulcerative disorders of the upper GI tract that require acid and pepsin for their formation. Ulcers differ from gastritis and erosions in that they extend deeper into the muscularis mucosa. The three common forms of peptic ulcers include Helicobacter pylori (HP)-associated ulcers, nonsteroidal antiinflammatory drug (NSAID)-induced ulcers, and stress-related mucosal damage (also called stress ulcers). 

Unlabeled Uses Prevention and treatment of stress-related mucosal damage, especially in acutely or critically ill patients treatment of gastric ulcer and rheumatoid arthritis relief of Gl symptoms associated with NSAlDs treatment of gastroesophageal reflux disease... 

Helicobacter pylori infection Nonsteroidal anti-inflammatory drugs Critical illness (stress-related mucosal damage)... 

Phillips JO, Metzler MH, Palmieri MT, et al. A prospective smdy of simph-fied omeprazole suspension for the prophylaxis of stress-related mucosal damage. Crit Care Med 1996 24 1793-1800. 

Stress-related mucosal damage—Superficial gastritis-like lesions associated with critical iUness in hospitalized patients. 

---