Streptomycin genetics

There should be no confusion between Eubacteria and Archaea, though both are unicellular and both lack nuclei and subcellular organelles. In addition to differences in the structures of certain RNA molecules, there are a number of other clear distinctions between the two domains. There are distinct sensitivities to antibiotics. For example, antibiotics such as kanamycin and streptomycin that are effective against a broad spectrum of bacteria have no effect on archaeans. Moreover, the genetic complement of Eubacteria and Archaea are distinct about 30% of all Archaea genes are unique to archaeans. Finally, the lipids that constitute the cell membrane are distinct. There are clear and compelling distinctions between these two great domains of life. 

Many applications of the aminoglycosides have been of historical significance in genetics and microbiology. For example, mutations to streptomycin resistance were employed as counterselective genetic markers in the historic experiments of William Hayes that demonstrated the existence of bacterial conjugation and the requirement of donor (Hfr or F-b) and receptor (F—) species. ... 

Gorini, L. Streptomycin and misreading of the genetic code. In Ribosomes Nomura, M. Tissieres, A. Lengyel, P., Eds. New York Cold Spring Harbor Laboratory, 1974 pp. 791-803. 

Piepersberg, W. Streptomycin and related aminoglycosides. In Biochemistry and Genetics of Antibiotic Biosynthesis Vining, L. Stuttard, C., Eds. Boston Butterworth-Heinemann, 1995 pp. 531-570. 

Piepersberg W, Streptomycin and related aminoglycosides In Vining LC, Stut-tard C (eds.), Biochemistry and Genetics of Antibiotic Biosynthesis Butterworths-Heinemann, Boston, MA, pp. 531—570, 1999. 

As with other antibiotics/-1 streptomycin is subject to inactivation by enzymes encoded by genetic resistance factors (Chapter 26). Among these are enzymes that transfer phospho groups... 

Rov 0-R Polyol Pathway The Biosynthesis of Streptomycin Osmotic Adaptation Genetic Diseases of Glycogen... 

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