Streptomyces spectabilis

Streptomyces spectabilis Spectinomycin Streptomyces spheroldes Novobiocin... 

As mentioned previously, the Stille reaction can also be combined with an elec-trocyclization. Trauner and coworkers [99] used this approach for the synthesis of a part of SNF4435C (6/1-190) and its natural diastereomer. SNF4435C, which was isolated from the culture broth of an Okinawan strain of Streptomyces spectabilis, acts as an immunosuppressant and multidrug resistance reversal agent [100]. In order to form the annulated cyclobutane skeleton in 6/1-190, the vinyl iodide... 

Spectinomycin Spectinomycin, 4a,7,9-trihydroxy-2-methyl-6,8-fcw-(methylamino)-per-hydroxypyrano-[2,3-b]benzodioxan-4-one (32.7.1), which is isolated from products of the actinomycete Streptomyces spectabilis, is an aminocyclitol, yet it is not an aminoglycoside antibiotic since it does not contain either an amino sugar region or a glycoside bond [316-324]. 

Spectinomycin is an aminocyclitol antibiotic produced by Streptomyces spectabilis. It is indicated for use via the oral and intramuscular or subcutaneous routes in the treatment of a variety of enteric, respiratory, and other infections of cattle, sheep, swine and poultry. Recommended dosages are 7.5-12.5 mg/kg bw for intramuscular injections and 1-5 mg/bird for subcutaneous injections in poultry. Spectinomycin is frequently combined with lincomycin and administered either intramuscularly at 15 mg/kg bw to calves, sheep, and swine (15), and at... 

A lyophilized culture of Streptomyces spectabilis, NRRL 2792, was used to seed the following sterile agar medium on tubed slants ... 

The streptovaricins, produced by Streptomyces spectabilis, are a complex mixture of closely related substances. Figure 7 shows the formulas of streptovaricins A-G and J. A summary account of the structural studies undertaken so far has been published by Rinehart4. The streptovaricins are chemically related to the rifamycins, but there are a number of important structural differences between the two groups, e.g. ... 

The spectinomycins (O Fig. 20) have a fused three-ring system which consists of a 4,5-disub-stituted actinamine and an ulose. Spectinomycin is produced by Streptomyces spectabilis and Streptomyces flavopersius. It has been clinically used for treatment of the gonorrhea infection. A related structure has been discovered with spenolimycin which was isolated from the culture filtrate of Streptomyces gilvospiralis. Efforts have been directed toward semisynthetic aminoglycoside antibiotics to treat multi-drug resistant bacteria [94]. 

Streptomyces spectabilis ATCC 27465 (medium 0) NT NT 3-MeOSAMMI 3-MeOSAMM2... 

AI1 microorganisms were grown only in medium a, while Streptomyces griseus ATCC 13968 and Streptomyces spectabilis ATCC 27465 were grown in both medium a and medium 6... 

Based on TLC analyses and control studies, only Streptomyces spectabilis ATCC 27465 (grown in medium 0) was shown to be capable of complete conversion of 3-methoxysampangine into two more polar compounds, designated 3-MeOSAMMl and 3-MeOSAMM2. Limitations in time and starting material for 3-methoxysampangine did not allow for preparative-scale fermentation studies. 

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