Streptomyces griseus component

Sequence 1, in Table I, is the sequence of trypsin, chymotrypsin, pancreatic elastase, thrombin, and other mammalian proteases, and it occurs throughout the animal kingdom down to invertebrates as primitive as the sea anemone (4). The Streptomyces griseus enzymes are from Pronase, a commercial enzyme preparation. Two of its components, Streptomyces griseus trypsin and protease A, not only have the Asp.Ser.Gly sequence, but they show several other homologies in sequence with the mammalian enzymes (5, 6), The same is true for the sequence of a-lytic protease, the Myxobacter 495 enzyme (7). 

The strain Streptomyces griseus has produced two other minor components, aplasmomycins B and C, under the cultural conditions described previously [48]. Recently, an aplasmomycin C-producing actinomycete was isolated from a sandy sediment sample in California [45]. 

Methyl ethers of Man, mono-substituted at the 2, 3, 4 or 6 positions have been reported in the lipopolysaccharides of photosynthetic procaryotes [82, 83]. The reducing end of the mannans from Mycobacterium smegmatis and Streptomyces griseus have a terminal a-O-methyl group on C-l and Man30Me in the polymer chain. The lactic acid ether 4-0-[-(S)-l- carboxyethyl]-D-mannose is a component of extracellular polysaccharides of Mycobacterium spp., and a-amino-3-0-[-... 

C30H21NO9, Mr 539.50, red powder, mp. >350 °C. A very effective cytotoxic antitumor antibiotic with additional activity against Gram-positive bacteria and fungi. F. A and the minor components F. B and f C are isolated from cultures of Streptomyces griseus. The antitumor activity of F. A is assumed to be due to the formation of free radicals which effect DNA strand cleavage. The water-soluble potassium salt of F. A has been developed for cancer therapy. In contrast to other antineoplastic substances F. A does not show any mutagenicity in the Ames test. 

II, Pseudocollagenase (Clostridium) Thermolysin (Bacillus subtilis)] Protease III, Staphylokinase (Staphylococcus aureus)-, Coccus P(Proteinase) (Serratia)-, Pronase component (Streptomyces griseus)-, P. roqueforti protease II ... 

Pronase a mixture of at least 4 proteolytic enzymes from Streptomyces griseus. TWo peptide esterase components resembling chymotrypsin and trypsin have been separated and further characterized. Both are inhibited by chicken ovoinhibitor. 

SzABO, G., Gy. Barabas, T. Valyi-Nagy, and Zs. Magyar A new component from the cell wall of Streptomyces griseus. 1. The role of streptomycin in the Ufe of Streptomyces griseus. Acta Microbiol. Acad. Sci. Hung. 12, 109 (1965). 

The following Streptomyces species Streptomyces coelicolor, S. lividans, S. parvulus, and S. griseus. The following are accepted as vector components of certified Host-Vector... 

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