Streptomyces antibiotic regulatory protein

Q-RT-PCR quantitative reverse polymerase chain reaction S ARP Streptomyces antibiotic regulatory protein... 

Galperin MY (2006) Structural classification of bacteritil response regulators diversity of output domains and domain combinations. J Bacteriol 188 4169-4182 Garg RP, Parry RJ (2010) Regulation of valanimycin biosynthesis in Streptomyces viridifaciens characterization of Vlml as a Streptomyces antibiotic regulatory protein (SARP). Microbiol 156 472-483... 

The complexity of the cascades of regulatory proteins is variable depending on the Streptomyces species. We will describe two examples of regulation of antibiotics with different structures. 

Fe catalyses most redox reactions in the cell (see Cytochromes). It is involved in the reduction of ribonucleotides to deoxyribonucleotides, is a coenzyme for aconitase (EC 4.2.1.3) in the tricarboxylic acid cycle, and is a component of a number of metalloflavo-proteins. It has a regulatory role in many microorganisms, e g. as an inhibitor of citrate synthesis in Aspergillus niger, and as a promoter of antibiotic synthesis by Streptomyces species. 

Wietzorrek A, Bibb M (1997) A novel feunily of proteins that regulates antibiotic production in strep-tomycetes appems to contain an OmpR-Uke DNA-binding fold. Mol Microbiol 25 1181-1184 Wilson DJ, Xue Y, Reynolds KA, Shermem DH (2001) Chtuacterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. J Bacteriol 183 3468-3475... 

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