Streptokinase release

Slow release drugs, 143 Solifpertine, 342 Sotalol, 41 Soterenol, 40 Spirilene, 292 Spi2 onolactone, 172 Stenbolone acetate, 155 Strecker reaction, 119 Streptokinase, 377 Sudoxicam, 394 Sulazepam, 403 Sulfabenzamide, 112 Sulfacytine, 113 Sulfanilamide, 112 Sulfanitran, 115 Sulfapyridine, 114 Sulfasalazine, 114 Sulfazamet, 113 Sulfonamide diuretics,... 

Fibrinolysis has recently been reviewed. In order for fibrinolysis to occur, the proenzyme plasminogen must be activated to plasmin by an activator. Several activators can be formed one from Hageman factor components after its activation, or by a tissue activator released from normal blood vessels. Urokinase is an activator considered to be limited in its function to the kidney. Streptokinase, a singlechain protein from 6-hemolytic streptococci, is an activator that has been studied for many years and has found clinical use especially in Europe. 

Anistreplase Prodrug streptokinase plus recombinant human plasminogen 1-2 hours Slowly releases streptokinase-activated plasminogen single bolus administration provides bng duration of action... 

Activation of human plasminogen by streptokinase requires the formation of a 1 1-complex, and it has been shown that the peptide at the NHj-terminus of plasminogen is not required to be released before cleavage of the arginyl-valine linkage that results in the formation of a two-chain plasmin molecule. This peptide is cleaved from native plasminogen or from the heavy-chain of plasmin in the streptokinase complex by free plasmin rather than by streptokinase-associated plasmin-... 

Fibrinolysis was followed by measuring release of radioactivity from I-prelabelled plasma, and was expressed as a percent of initial fibrin content of networks. Networks were washed with Tris-HCl saline buffer (pH 7.35, ionic strength 0.153 M) for 24 hours with three changes of buffer and placed in tubes containing equal volumes of plasma and Tris-HCl saline buffer. The tubes were then rotated in an elliptical rotator at 37 C and fibrinolysis was induced with streptokinase (KabiVitrium, Stockholm, Sweden). The release of I-fibrin was monitored as an index of the rate of lysis. 

Figure 5. Susceptibility to lysis with streptokinase (2,500 lUml" ) in networks developed with bovine thombin or O. scutellatus venom. The fibrin released has been expressed as a percent of initial fibrin content of networks.

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