Drugs slow release

Slow release drugs, 143 Solifpertine, 342 Sotalol, 41 Soterenol, 40 Spirilene, 292 Spi2 onolactone, 172 Stenbolone acetate, 155 Strecker reaction, 119 Streptokinase, 377 Sudoxicam, 394 Sulazepam, 403 Sulfabenzamide, 112 Sulfacytine, 113 Sulfanilamide, 112 Sulfanitran, 115 Sulfapyridine, 114 Sulfasalazine, 114 Sulfazamet, 113 Sulfonamide diuretics,... 

The hydrolysis of esters is usually rapid whilst that of amides if often much slower. This makes esters suitable as prodrugs (see Section 9.8) and amides a potential source for slow release drugs. 

Gelatin-poly(acrylic acid) In rats Slow-release drug delivery system with good adhesive characteristics 89... 

Phendimetrazine. Phendimetrazine is readily absorbed from the GI tract after an oral dose in humans. It exhibits a short plasma half-life = 1.9 h), primarily attributable to high clearance, and requires qid dosing to maintain adequate plasma levels (78). A special slow-release drug capsule has been developed that extends the half-life to 9.8 h. Two primary metabolites, phenmetrazine (61) and phendimetrazine N-oxide (62), are formed by N-dealkylation and N-oxidation and are cleared through the kidney (79). 

Benjamin EJ, Lin LH. Preparation and in vitro evaluation of salts of an anlihyperlensive agent to obtain slow release. Drug Dev Ind Pharm 1985 11 771-790. 

Although the hydrolytic stability of some phosphazene polymers makes them attractive as structural materials, it is possible to create hydrolytically sensitive phosphazenes that may be useful medically as slow-release drugs. Steroids, antibiotics, and catecholamines (e.g.. dopamine and epinephrine) have been linked to a polyphosphazene skeleton (Fig. 16.27) with the intention that slow hydrolysis would provide these drugs in a therapeutic steady state. ... 

However, there is particular interest in the development of slow-release drug delivery systems (123,124) seen in Fig, 19 or in selectively transferring drugs into the lymphatic system using W/O/W emulsions. W/O/W emulsions... 

Starch 1. Slow release drug delivery system based on amylose-rich starch has been marketed under the trade name Contramid . 2. Starch microspheres have been investigated as a bioadhesive drug delivery system for the nasal delivery of proteins. Khanlari and Dube (2013), Nair and Laurencin (2006), and Marques et al. (2002)... 

Unlike most pol nmers (except poly(amino acids), poly (lactic acid), or poly(glycolic acid)), compounds such as XX hydrolyze slowly to yield ethanol, amino acid, phosphate, and ammonia. Thus, the polymer is biocompatible in the sense that it decomposes to materials that can be metabolized or excreted. Recent work in our laboratory has exploited the linkage of steroid molecules (XXI) to a polyphosphazene skeleton with a view to the utilization of these compounds as slow-release drugs. Furthermore, we have recently examined the use of poly[bis(methylamino)-phosphazene], [NP(NHCH3)2]n> a coordinative ligand for... 

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