Strengths and Limitations

Analysis of the ability of in vitro genotoxicity tests to predict carcinogenicity in 

(1971). The detection of chemical mutagens with enteric bacteria. In Chemical Mutagens, Principles and Methods for Their Detection, Vol. 1, ed. H. Hollaender. Plenum Press, New York, pp. 267-282. 

Durston, W. E., Yamasaki, E., and Lee, F. D. (1973). Carcinogens are mutagens A simple test system combining liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci USA 70, 2281-2285. 

and Tennant, R. W. (1988). Chemical stracture, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the 

Avlasevich, S. L., Bryce, S. M., Cairns, S. E., and Dertinger, S. D. (2006). In vitro micronucleus scoring by flow cytometry Differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability. Environ Mol Mutagen 47, 56-66. 

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Lee P A, Citrin P H, Eisenberger P and Kincaid B M 1981 Extended x-ray absorption fine structure—its strengths and limitations as a structural tool Rev. Mod. Rhys. 53 769-806... 

The purpose of this projeet is to gain familiarity with the strengths and limitations of the Gauss-Seidel iterative method (program QGSEID) of solving simultaneous equations. 

H = History if a plant has used material successfully for many years, and the staff members know its strengths and limitations, how to weld it, etc., hesitate before making a change. For example, a fiberglass-reinforced plastic had given excellent service for many years when another composite from the same company, with the same name but a different number, was used instead, it failed overnight. 

Each investment metric has strengths and limitations. For example, the simple payback time indicates the time required to recover the investment, hut it ignores any benefits that may occur after the payback time, so measures offering many years of benefits appear no better than short-lived ones. A common drawback of these investment metrics is that the price of energy must be assumed. If the energy price changes, then the payback time must be recalculated. 

Fontaine, A., Dartyge, E., Itie, J. P., Juchs, A., Polian, A., Tolentino, H. and Tourillon, G. Time-Resolved X-Ray Absorption Spectroscopy Using an Energy Dispensive Optics Strengths and Limitations. 151, 179-203 (1989). 

Schirmer has succinctly summarized the strengths and limitations of phase solubility analysis [40]. The principal advantages are that (1) a reference standard known purity is not required, (2) the number and types of impurities in the sample need not be known, (3) all required solubility information is obtained from the analysis, (4) the technique can be applied to the analysis of any solute that can be dissolved in some solvent, (5) the deduced results are both precise and... 

Chemical probes such as titrations using Hammett indicators [188,189] and test reactions [190] have been often employed as well. Given that each method has its own strengths and limitations, a rational combination of specific techniques is often the best approach to the study of a given catalytic system. 

As discussed above, NMR can be a useful tool for the determination of dissociation constants provided that its strengths and limitations are recognized. In practice, it is only... 

Whilst the first part of this book deals mainly with concepts and theories of alternatives to the use of organic solvents as reaction media, the later Chapters (Chapters 7-11) look at some applications of these methods and compare their strengths and limitations as illustrated by these case studies. 

The remainder of this introduction will involve a brief discussion of previous work in the area of semiconductor electrodeposition. The focus will be on the strengths and limitations of the various electrodeposition methods with regard to controlling deposit structure, composition, and morphology. Most of this work has been well reviewed by others [13,40-44]. 

Strengths and Limitations of Pharmacophore-Based Virtual Screening... 

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