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Strategies with Cancer Immunotherapy

IL-12 may also be potentially useful for adoptive immunotherapy, especially in immunosuppressed patients (caused by cancer or HIV infection) with decreased NK function and T-cell cytotoxicity. Under appropriate conditions, IL-12 has therapeutic efficacy for promoting defense against a variety of pathogens and for use as a vaccine adjuvant to enhance beneficial Thl over detrimental Th2 lymphocyte responses and provides new tools for the development of treatment and adjuvant strategies to potentiate beneficial or inhibit detrimental endogenous immune responses. ... [Pg.686]

Investigational Approaches. Despite the significant reduction in cancer recurrence and increased survival afforded with fluorouracil-based adjuvant chemotherapy, the results obtained thus far indicate need for continued improvement. Several strategies are underway, including protracted fluorouracil infusion, oral fluorinated pyrimidines, irinotecan, oxaliplatin, and immunotherapy-based therapies. ... [Pg.2400]

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Immunotherapy

Immunotherapy with

Immunotherapy, cancer

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