Stramonium cigarettes

Jimsonweed Daturia stramonium 0.1%-0.6% hyoscyamine in ripe seeds, leaves, flowers Anticholinergic toxicity Seeds may be chewed or leaves smoked as cigarettes... 

Datura stramonium Jimson weed, devil s weed, Thorn apple. Contains atropine, hyoscine, hyoscyamine. Stramonium tea and cigarettes used to be used for asthma. Dilated pupils, mania, red skin colour (dilated vessels and no sweating) thirst, tachycardia, vomiting, convulsions. 100-125 seeds lethal. Death uncommon. Datura was apparently used in India by poisoners to remove idiots from positions of high rank. 

Bronchodilation is another property of belladonna alkaloids of potential usefulness. Due to relaxation of the smooth musculature of bronchial passageways, this effect has found applications in asthma and other pulmonary obstructive conditions. At one time the smoking of cigarettes made of stramonium leaves was popular. More recently, atropine, quater-nized with isopropyl bromide (Ipratropium, Fig. 8-13) has been introduced as an aerosol for inhalation. This renewed interest in antimuscarinics resulted in part from clarifications of the role of the parasympathetic system in bronchial obstructions. The availability of a potent agent such as atropine in a poorly absorbed form (i.e., quatemized) would minimize systemic effects following inhalation. Ipratropium bromide does not cross the BBB. It is longer acting and more bronchoselective than atropine methylbromide and exhibits no CNS effects. 

Figure 1 Asthma cigarettes containing shredded stramonium leaves.

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