Storage and Process-induced Phase Transformations

Confocal Raman microscopy, equipped with XYZ mapping to examine spatially resolved samples, is increasingly being used to assess the identity and content uniformity of solid state forms in low dose formulations. Solid state NMR spectroscopy, by virtue of its ability to detect specific nuclei with site selectivity, is also particularly well suited to characterizing component phases in bulk formulations. While in many cases the basic CP/MAS NMR technique is sufficiently sensitive and afibrds ample peak resolution for phase 

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