Stoichiometry Balancing Methods Applied in Bioprocess Design

1 Stoichiometry (Balancing Methods) Applied in Bioprocess Design 

As a consequence of the increased worldwide competition in bioprocessing compared with chemical processing, considerable attention has been directed toward improvement in the efficiency of technical bioprocesses. In this situation, formulating balanced stoichiometric equations is a powerful technique. Taking a general case of (cf. Equ. 2.8)  

Generally, there are two many unknowns (e.g., 15). In case the composition of iS, X, and P are known a,b,c a,jS,y,(5 a, jS, 7, ) there remain only six unknowns in four equations, which can then be solved using supplementary information, for example, on the basis of gas analysis (02,C02). 

Generally there are two points of interest. The first is, what effect does the conversion yield have on the cost of production The second is, how much room is there for improvement how do actual yields compare with theoretical values  

Other important results concern the glucose balance and the effect of glucose feed rate schemes in fed-batch cultures. It was shown by this analysis 

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