Stimulus type chemically dependent stimuli

The speed with which taste stimulation occurs, coupled with the fact that stimulation with toxic substances does no damage to the receptors, led Beidler to suggest that taste stimulus need not enter the interior of the taste cell in order to initiate excitation. Because a taste cell has been shown to be sensitive to a number of taste qualities, and to a large number of chemical stimuli, he and his coworkers concluded that a number of different sites of adsorption must exist on the surface of the cell. Therefore, they assumed that taste response results from adsorption of chemical stimuli to the surface of the receptor at given receptor sites. This adsorption is described by a monomolecular reaction similar to that assumed by Renqvist, Lasareff, and Hahn, but with a difference. From the fact that each type of chemical-stimulus compound has a unique level of saturation of the taste receptor, it was concluded that the magnitude of the response is dependent on the initial reaction with the receptor, and not on other, subsequent receptor-reactions that are common to all types of receptor stimulation. Therefore, it was assumed that the magnitude of neural response is directly proportional to the number of sites filled, the maximum response occurring when all of the sites are filled. Beidler derived a fundamental... 

Young et al. [4] propose a reverse engineering method in which they start with general chemical kinetic equations (see eq. (11.1)) and then linearize these equations (see eq. (11.3)) for the concentrations of each mRNA in the system the time variation of each mRNA is a linear function of its own concentration a linear function of all other mRNA concentrations with coefficients that give the type (positive, negative, or zero) and strength of interaction between two mRNAs a constant perturbation term (external stimulus) and a noise term dependent on time only. The coefficients form the connectivity matrix. The system of these N mRNAs is originally presumed to be in a stationary... 

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