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Stimulus Responsive Drug Release

Sutani, K., Kaetsu, L, Uchida, K. and Matsubara, Y. (2002). Stimulus responsive drug release from polymer gel Controlled release of ionic drug from polyampholyte gel. Radiation Physics and Chemistry, 64,331-336. [Pg.269]

In 2000, the first example of ELP diblock copolymers for reversible stimulus-responsive self-assembly of nanoparticles was reported and their potential use in controlled delivery and release was suggested [87]. Later, these type of diblock copolypeptides were also covalently crossUnked through disulfide bond formation after self-assembly into micellar nanoparticles. In addition, the encapsulation of l-anilinonaphthalene-8-sulfonic acid, a hydrophobic fluorescent dye that fluoresces in hydrophobic enviromnent, was used to investigate the capacity of the micelle for hydrophobic drugs [88]. Fujita et al. replaced the hydrophilic ELP block by a polyaspartic acid chain (D ). They created a set of block copolymers with varying... [Pg.88]

Bio-responsive release the system modulates drug release in response to a biological stimulus (e.g. blood glucose levels triggering the release of insulin from a dmg delivery device). [Pg.56]

FIGURE 12.17 Schematic representation of polypyrrole electropolymerized on a gold surface to form an electrically responsive nanoporous membrane. A reversible change of pore size between oxidation and reduction states is observed in response to an electrical stimulus. By loading a therapeutic in the pores and applying an electrical stimulus, it is possible to modulate the drug release rate [234]. [Pg.400]

Vasani RB, Mclnnes SJP, Cole MA, Jani AMM, EUis AV, Voelcker NH (2011) Stimulus-responsiveness and drug release from porous sihcon films ATRP-grafted with poly(-V-isopropylacrylamide). Langmuir 27 7843... [Pg.215]

Journal of Applied Polymer Science 74, No.7, 14th Nov. 1999, p. 1752-61 DRUG RELEASE BEHAVIOR OF ELECTRICAL RESPONSIVE POLY(VINYL ALCOHOL)/ POLY(ACRYLIC ACID) IPN HYDROGELS UNDER AN ELECTRIC STIMULUS So Yeon Kim Young Moo Lee Hanyang,University... [Pg.96]

Figure 8.4 Various stimulus responsible for drug release from smart polymeric drug delivery systems with responsive material. Figure 8.4 Various stimulus responsible for drug release from smart polymeric drug delivery systems with responsive material.
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Drug release

Release response

Stimulus

Stimulus-response

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