Stimulants receptor studies

By means of intracellular recording and staining methods, we have examined the responses of AL neurons to stimulation of the ipsilateral antenna with each of the sex pheromone components as well as partial and complete blends (75). In accordance with results of behavioral and sensory-receptor studies, components A and B are the most effective and potent sex pheromone components for eliciting physiological responses in the male-specific AL neurons. On the basis of these responses, we classified the neurons into two broad categories pheromone generalists and pheromone specialists (76). Pheromone generalists are neurons that respond similarly to stimulation of either the component A input channel or the component B input channel and do not respond differently when the complete, natural pheromone blend is presented to the antenna. In contrast, pheromone specialists are neurons that can discriminate between antennal stimulation with component A and stimulation with component B. There are several types of pheromone specialists. Some... 

Indirect evidence for hypothalamic CRF hypersecretion comes from CRF stimulation test studies in which patients with depression typically show blunted ACTH responses, likely reflecting, in part, down-regulation of pituitary CRF receptors. These findings are similar to the reduction of pituitary CRF receptors in maternally... 

Southeast Asian Strychrtos spp., Loganiaceae, Ang./rodenticide, animal stimulant, and ligand for glycine receptor studies... 

The studies of Goldberg and colleagues have been and remain pioneering in not one but at least two fronts. First, the concepts and demonstration of vascular dopamine receptors has allowed and stimulated detailed studies of the location, function, mechanism, and role of peripheral dopamine and dopamine receptors. Second, their work led to and accelerated the utilization of dopamine agonists in clinical medicine with the use of intravenously administered dopamine for shock and heart failure being the best example. 

IL-2 Receptor Studies. Studies of the IL-2 receptor have been performed with S-iaet-IL-2 and H-leu, 3H-lys-IL-2 prepared by stimulation of... 

Other auxin-like herbicides (2,48) include the chlorobenzoic acids, eg, dicamba and chloramben, and miscellaneous compounds such as picloram, a substituted picolinic acid, and naptalam (see Table 1). Naptalam is not halogenated and is reported to function as an antiauxin, competitively blocking lAA action (199). TIBA is an antiauxin used in receptor site and other plant growth studies at the molecular level (201). Diclofop-methyl and diclofop are also potent, rapid inhibitors of auxin-stimulated response in monocots (93,94). Diclofop is reported to act as a proton ionophore, dissipating cell membrane potential and perturbing membrane functions. 

Researchers at the MoneU Center (Philadelphia, Pennsylvania) are using a variety of electrophysical and biochemical techniques to characterize the ionic currents produced in taste and olfactory receptor cells by chemical stimuli. These studies are concerned with the identification and pharmacology of the active ion channels and mode of production. One of the techniques employed by the MoneU researchers is that of "patch clamp." This method aUows for the study of the electrical properties of smaU patches of the ceU membrane. The program at MoneU has determined that odors stimulate intraceUular enzymes to produce cycUc adenosine 3, 5 -monophosphate (cAMP). This production of cAMP promotes opening of the ion channel, aUowing cations to enter and excite the ceU. MoneU s future studies wiU focus on the connection of cAMP, and the production of the electrical response to the brain. The patch clamp technique also may be a method to study the specificity of receptor ceUs to different odors, as weU as the adaptation to prolonged stimulation (3). 

Fig. 11. Dose—response curves for (A,A) inhibition of cyclic AMP formation and stimulation of IP formation by carbachol (A,D) before and (A,H) after reduction of receptor number by irreversible alkylation (carbachol) is in M. Error bars ( ) are shown for some studies.

---