Stilbenoid phenols

Combretastatin A-4 Stilbenoid phenol Combretastatin A-4 Oncology Tubulin binding Phase I/imil OXIGENE 644-650... 

Combretastatin A-1 Stilbenoid phenol OXi4503 Oncology Tubulin binding Phase I/II OXiGENE 652-657... 

Because of fhe medicinal relevance of stilbenoids, a solid-phase approach using CM has been recently disclosed [228]. Thus, 4-viriyl phenol (115) was attached to a Merrifield resin and subjected to CM wifh various substituted styrenes in benzene at 80 °C for 12 h in fhe presence of Grubbs rufhenium-carbene catalyst (Scheme 27). 

Some microbial pathogens can circumvent the defensive response of plants by biotransforming the antimicrobial stilbenoids in a multi-step oxidative detoxification process [106], Research has shown that the pathogenicity of B. cinerea strains is positively correlated with these fungi s production of blue-copper oxidases known as stilbene oxidases or laccases [127,128]. These enzymes are polyphenol oxidases capable of catalyzing the oxidation and polymerization of numerous phenolic substrates [129,130,131,132]. It has been shown that 1 is readily transformed in the presence of B. cinerea culture medium filtrates that contain laccases [107]. Recently, six resveratrol dimers (restrytisols A-C... 

Elavanols Elavonols Cinnamic acid Phenolic acids Stilbenoid 15 Carrot, tomato, broccoli, onion, garlic, pepper, beetroot QuECHERS + clean up Acetonitrile ethylacetate (50 50) 15 min + clean up 78-99 [51]... 

Type III polyketide synthases are particularly relevant to this chapter because they catalyze the formation of phenolic compounds. This group of polyketide synthases consists of CHSs, stilbene synthase (STS), and curcuminoid synthase (CUS), which perform decarboxylative condensations between a starter unit, either p-coumaroyl-CoA 19 or cinnamoyl-CoA 18, and an extender unit, malonyl-CoA 10. CHS, STS, and CUS convert the substrate molecules into flavo-noids (Cg-Cs-Cg), stilbenoids 8 (Cg-C2-Cg), and curcuminoids 9 (Cg-C7-C6), respectively [59]. Stilbenoids 8 and curcuminoids 9 are out of the scope of this chapter but possess medicinal properties as well resveratrol is a well-known stilbenoid 8 associated with longevity, and curcumin is a common curcuminoid 9 that is responsible for the yellow color in turmeric and can be utilized as a natural pigment possessing antioxidant and anti-inflammatory properties [60-63]. For an in-depth treatment of plant polyketide production in microbes, the reader is directed to a recent comprehensive review by Boghigian et al. [64]. 

Phenolic acids, flavonoids, stilbenoids. Phenomenex Water-acetonitrile, both with 0.1 % ESI- [7]... 

Polyphenolics are important constituents of grapes in determining the color, taste, and body of wines. Unlike other alcoholic beverages, red wine, which is obtained after about 10 days of maceration, contains phenolic compounds in substantial concentrations of up to 4 g L . Due to the lower maceration time, white and rose wines contain about a tenth of the polyphenol levels of red wines [1]. Among these compounds, stilbenoids constitute an important subclass, whose overall levels can reach over 100 mg in red wine. Resveratrol is one of the major stilbenoids of red wine with numerous promising biological activities. 

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