SREBPs sterol regulatory-element-binding

SREBP sterol regulatory element binding protein... 

In mammals, the liver is the organ most active in lipids synthesis, and in this organelle, the transcription factors SREBPs (sterol-regulatory element binding protein) play crucial roles in lipids homeostasis. In addition to cholesterol,... 

Fig. 6. Coordinated transcriptional regulation of fatty acid desaturases and elongases in mammals. PUFA, polyunsaturated fatty acids +, stimulation inhibition LXR, liver X receptor RXR retinoid X receptor SREBP, sterol regulatory element binding protein ChREBP, carbohydrate response element binding protein Mix, Max-like receptor PPAR-ot, peroxisome proliferator activated receptor alpha LXRE, liver X receptor response element SRE, sterol response element ChoRE, carbohydrate response element PPRE, peroxisome proliferator response element. (See color plate section, plate no. 6.)...

SREBP Sterol regulatory element-binding proteins 1 and 2... 

Several key enzymes in this pathway can be activated through DNA transcriptional regulation of SREBP (sterol regulatory element-binding proteins 1 and 2) [12]. Also, the regulation of this pathway can be achieved by controlling the rate of translation of the mRNA, as well as the level of reductase and kinase (degradation of reductase and phosphorylation). 

Osborne TF. Sterol regulatory element binding protein (SREBPs) Key regulators of nutritional homeostasis and insulin action. J Biol Chem 2000 275 32379-32382. 

FIGURE 21-43 SREBP activation. Sterol regulatory element-binding proteins (SREBPs, shown in green) are embedded in the ER when first synthesized, in a complex with the protein SREBP cleavage-activating protein (SCAP, red). (N and C represent the amino and carboxyl termini of the proteins.) When bound to SCAP, SREBPs are inactive. When... 

Includes a timely new discussion on the regulation of cholesterol metabolism at the genetic level, with consideration of sterol regulatory element-binding proteins (SREBPs). 

Shimano, H. 2001. Sterol regulatory element-binding proteins (SREBPs) transcriptional regulators of lipid synthetic genes. Prog. Lipid Res. 40, 439-452. 

Members of a family of nuclear transcription factors called sterol regulatory element-binding proteins (SREBP) are responsible for the regulation of these cholesterol feedback mechanisms. SREBP are able to activate a number of genes encoding for proteins involved in the homeostasis of cholesterol and other lipids, including the LDL receptor gene itself. 

Kim, H. J.,Takahashi, M., and Ezaki, 0.1999. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-lc mRNA in mouse liver a possible mechanism for down-regulation of lipogenic enzyme mRNAs. J. Biol. Chem.,274, 25892-25898. 

Fatty acid synthase is transcriptionally regulated by upstream stimulatory factor and sterol regulatory element binding protein Ic (SREBP-lc), in response to feeding/insulin. 

The sterol regulatory-element-binding proteins (SREBPs)... 

Mullen, E., Brown, R. M., Osborne, T. R, Shay, N. F. (2004). Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells. J. Nutr., 134, 2942-2947. 

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