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Steroids steroid 21-monooxygenase

This heme-thiolate-dependent enzyme [EC 1.14.99.9], also known as steroid 17a-monooxygenase, catalyzes the reaction of a steroid with AH2 and dioxygen to produce a 17a-hydroxysteroid, A, and water. [Pg.657]

Spironolactone exhibits antiandrogenic effects in males and females. It decreases testosterone biosynthesis by inhibiting steroid 17a-monooxygenase (17a-hydroxylase) activity, possibly secondary to destruction of microsomal cytochrome P-450 in tissues with high steroid 17a-monooxygenase activity (testes, adrenals) [65],... [Pg.306]

Steroid monooxygenase Cylindrocarpon radicicola ATCC 11011 1 2 identical subunits NADPH 115 (56 each) 1 FAD per subunit 7.8 [83]... [Pg.1215]

Furuya T, Shibata D, Kino K (2009) Phylogenetic analysis of Bacillus P450 monooxygenases and evaluation of their activity towards steroids. Steroids... [Pg.378]

Ouellet H, Guan S, Johnston JB, Chow ED, Kells PM, BurUngame AL, Cox JS, Podust LM, Ortiz de Montellano PR (2010) Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intraeellularly generated eholest-4-en-3-one. Mol Mierobiol 77 730-742... [Pg.390]

Steroid 17(X-monooxygenase 2 steroid 21-monooxygenase 3 steroid 11 -monooxygenase 4 dehydrogenase 5 corticosterone 18-monooxygenase, steroid 18-oxidase... [Pg.241]

Steroid 17a-monooxygenase 2 steroid C-17, C-20 lyase 3 17jff-hydroxysteroid dehydrogenase 4 3-oxo-5a-steroid Zl -oxidoreductase... [Pg.244]

Steroid 19-monooxygenase 2 steroid 19-oxidase 3 steroid C-10, C-19-lyase 4 17j -hydroxy-steroid dehydrogenase... [Pg.246]

Another way of altering the substrate specificity of PAMO was shown in 2012 by creating some chimeric biocatalysts [38]. Thus, using structure-inspired subdomain exchange, PAMO was blend with CHMO. or steroid monooxygenase (STMO) from Rhodococcus rhodochrous. For this, 106 amino acids corresponding to the... [Pg.154]

Proton Pump Inhibitors and Acid Pump Antagonists retinoid X receptor (RXR) and is also activated by various lipophilic compounds produced by the body such as bile acids and steroids. PXR heterodimerized with RXR stimulates the transcription of cytochrome P450 3A monooxygenases (CYP3A) and other genes involved in the detoxification and elimination of the... [Pg.998]

Cytochromes P450 Are Monooxygenases Important for the Detoxification of Many Drugs for the Hydroxylation of Steroids... [Pg.89]

See other pages where Steroids steroid 21-monooxygenase is mentioned: [Pg.96]    [Pg.96]    [Pg.96]    [Pg.111]    [Pg.112]    [Pg.422]    [Pg.422]    [Pg.422]    [Pg.96]    [Pg.96]    [Pg.307]    [Pg.307]    [Pg.308]    [Pg.344]    [Pg.96]    [Pg.96]    [Pg.96]    [Pg.1203]    [Pg.1214]    [Pg.78]    [Pg.87]    [Pg.95]    [Pg.2750]    [Pg.2750]    [Pg.299]    [Pg.360]    [Pg.361]    [Pg.194]    [Pg.65]    [Pg.349]    [Pg.107]    [Pg.108]    [Pg.110]    [Pg.216]    [Pg.70]   
See also in sourсe #XX -- [ Pg.422 ]



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Steroid monooxygenase

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