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Testosterone biosynthesis

Figure 42-5. Pathways of testosterone biosynthesis. The pathway on the left side of the figure is called the or dehydroepiandrosterone pathway the pathway on the right side is called the A" or progesterone pathway. The asterisk indicates that the 17a-hydroxy-lase and 17,20-lyase activities reside in a single protein, P450cl7. Figure 42-5. Pathways of testosterone biosynthesis. The pathway on the left side of the figure is called the or dehydroepiandrosterone pathway the pathway on the right side is called the A" or progesterone pathway. The asterisk indicates that the 17a-hydroxy-lase and 17,20-lyase activities reside in a single protein, P450cl7.
Permethrin may behave like estrogen in females but antiandrogen in males when administered to immature female and male rats at 10-800 mg/kg [154]. Treatment of rats with permethrin at 10 mg/kg/day during gestation produced fetal death and feminization of male fetuses [155]. Reductions in sperm count and motility and in serum testosterone were noted in a 6-week repeated dose study in mice at 35 mg/kg/day. Permethrin may cause mitochondrial membrane impairment in Leydig cells, resulting in inhibition of testosterone biosynthesis [156]. [Pg.103]

Zhang SY, Ito Y, Yamanoshita O et al (2007) Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of Leydig cells in adult male mouse. Endocrinology 148 3941-3949... [Pg.112]

Spironolactone exhibits antiandrogenic effects in males and females. It decreases testosterone biosynthesis by inhibiting steroid 17a-monooxygenase (17a-hydroxylase) activity, possibly secondary to destruction of microsomal cytochrome P-450 in tissues with high steroid 17a-monooxygenase activity (testes, adrenals) [65],... [Pg.306]

Fig. 10. Pathways of androgen biosynthesis in rat testis. A — B —> C and a —> b - c are the A5 and xlJ pathways, respectively, for testosterone biosynthesis. Enzymes A.a. 17-hydroxylase B.b, C-17,20-lyase C,c, 17j3-HSD. Reaction c is reversible. Fig. 10. Pathways of androgen biosynthesis in rat testis. A — B —> C and a —> b - c are the A5 and xlJ pathways, respectively, for testosterone biosynthesis. Enzymes A.a. 17-hydroxylase B.b, C-17,20-lyase C,c, 17j3-HSD. Reaction c is reversible.
Finasteride 5a-Reductase inhibitor (testosterone biosynthesis inhibitor)... [Pg.62]

Schurmeyer T, Nieschlag E. Effect of ketoconazole and other imidazole fungicides on testosterone biosynthesis. Acta Endocrinol 1984 105 275-80. [Pg.339]

HI. Hagen, A. A., and Eik-Nes, K. B., Testosterone biosynthesis in the canine in vivo following infusion of 17a-hydroxy (4t- [Pg.207]

Luteinizing hormone binds to its receptor on the surface of the Leydig cells to initiate testosterone biosynthesis. As in other endocrine cells, the binding of gonadotropin activates the Gs signal transduction pathway, increasing intracellular cyclic adenosine monophosphate (cAMP) levels via activation of adenylate cyclase. One of the processes influenced by elevated cAMP levels is the... [Pg.1999]

Androstenedione, mdrosl-4-ette-3,l7-dionc a weak androgen, and an intermediate in testosterone biosynthesis (see Androgens). [Pg.41]

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