Steroids biochemical reductions

Silva CM, Cidlowski JA. The effect of oxidation/reduction on the charge heterogeneity of the human glucocorticoid receptor. J Steroid Biochem Mol Biol 1992 41 1-10. 

Reduction of estrogen-induced transformation of mouse mammary epithelial cells by N-acelylcysteine. J. Steroid Biochem. Mol. Biol, 109, 22-30. 

Gibb, W., Jeffery, J. The steric course with respect to the reduced nicotinamide-adenine dinucleotide of the reduction of 3-oxo steroids catalyzed by cortisone reductase. European J. Biochem. 34, 395—400 (1973). 

Gibb, W., Jeffery, J. Reduction of the non-steroid adamantanone by crystalline preparations of cortisone reductase. Biochem. J. 126, 443 (1972). 

Zielinski RJ, Roose SP, Devanand DP, et al Cardiovascular complications of ECT in depressed patients with cardiac disease. Am J Psychiatry 150 904-909, 1993 Zimmerberg B, Farley MJ Sex differences in anxiety behavior in rats role of gonadal hormones. Physiol Behav 54 1119-1124, 1993 Zimmerberg B, Brunelli SA, Hofer MA Reduction of rat pup ultrasonic vocalizations by the neuroactive steroid allopregnanolone. Pharmacol Biochem Behav 47 735-738, 1994... 

As is the case for other steroids, the Hver is the primary site for the inactivation of estrogens. The main biochemical reactions are hydroxylation, oxidation, reduction, and methylation. Conjugation with glucuronic or sulfuric acid, which imparts more water solubility to these steroids and thus allows them to be eliminated rapidly through the... 

Cholesterol is primarily restricted to eukaryotic cells where it plays a number of roles. Undoubtedly, the most primitive function is as a structural component of membranes. Its metabolism to bile acids and the steroid hormones is relatively recent in the evolutionary sense. In this chapter, the pathway of cholesterol biosynthesis will be divided into segments which correspond to the chemical and biochemical divisions of this biosynthetic route. The initial part of the pathway is the 3-step conversion of acetyl-CoA to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). The next is the reduction of this molecule to mevalonate, considered to be the rate-controlling step in the biosynthesis of polyisoprenoids. From thence, a series of phosphorylation reactions both activate and decarboxylate mevalonate to isopen tenyl pyrophosphate, the true isoprenoid precursor. After a rearrangement to the allylic pyrophosphate, dimethylallyl pyrophosphate, a sequence of l -4 con-... 

In its classical biochemical role as cofactor for hydroxylases involved in collagen, steroid, neurochemical, and carnitine biosyntheses, ascorbate acts as a biological reductant for ferric (Fe +) and cupric (Cu " ) ions (Englard and Seifter, 1986). More recently, ascorbate has been shown to be an effective plasma and cellular antioxidant, donating electrons to quench reactive free radicals that cause in vivo oxidative damage linked to a variety of degenerative diseases (Bendich et... 

Hirakawa, H., Kamiya, N., Yata, T., and Nagamune, T. (2003) Regioselective reduction of a steroid in a reversed micellar system with enzymatic NADH-regeneration. Biochem. Eng.]., 16, 35-40. 

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