Steroid estrogen receptor

Y Hori, Y Abe, M Ezaki, T Goto, M Okuhara, M Kohsaka. R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. I. Taxonomy, fermentation, isolation, and biological properties. J Antibiot 46 1055-1062, 1993. 

Steroids Estrogen Receptor Complexed with 17p-Estradio and Raloxifene... 

Hori Y, Abe Y, Shigematsu N, Goto T, Okuhara M, Kohsaka M. Napyradiomycins A and Bl non-steroidal estrogen-receptor antagonists produced by a Streptomyces. J. Antibiot. 1993 46(12) 189(U1893. 

The great variety of structures that have by now been shown to exhibit estrogenic activity leads to the suspicion that the estrogen receptor may be unusually nonspecific compared to receptors for other steroid hormones. 

Although estrone and estradiol (26) have both been isolated from human urine, it has recently been shown that it is the latter that is the active compound that binds to the so-called estrogen receptor protein. Reduction of estrone with any of a large number of reducing agents (for example, any of the complex metal hydrides) leads cleanly to estradiol. This high degree of stereoselectivity to afford the product of attack at the alpha side of the molecule is characteristic of many reactions of steroids. 

Sex Steroid Receptors Andr ogen Receptor, Estrogen Receptors, Progesterone Receptor... 

Sex Steroid Receptors Androgen Receptors, Estrogen Receptors, Pregesterone Receptor... 

Sex steroid receptors are members of the steroid hormone receptor (SHR) family that ligand-dependently regulate functions of the sexual organs. Sex steroid receptors are the androgen receptor [1] (AR), the estrogen receptor a [2] and (3 [3] (ERa, ER 3), and the progesterone receptor [4] (PR). 

Sex Steroid Receptors Androgen Receptor, Estrogen Receptors, Progesterone Receptor. Figure 1 Schematic structures of AR, ERa, ER(3, and PR. 

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