Steroid dioxygenase

Steroid dioxygenase (E.C. 1.13.11.25 - 3,4-Dihydroxy-9,10-seco-androsta-l,3,5(10)-triene-9,17-dione oxygen 4,5-oxidoreductase... 

SALICYLATE 1-MONOOXYGENASE SARCOSINE OXIDASE STEROID HYDROXYLASES SULFITE OXIDASE SULEUR DIOXYGENASE THYMIDINE 2 -HYDROXYLASE TOLUENE DIOXYGENASE XANTHINE OXIDASE... 

Other names Homoprotocatechuate oxygenase Protocatechuate 4,5-oxygenase Steroid 4,5-dioxygenase 3-Alkylcatechol 2,3-dioxygenase... 

Dairam A, Antunes EM, Saravanan KS, Daya S (2006) Non-steroidal anti-inflammatory agents, tolmedn and sulindac, inhibit liver tryptophan 2,3-dioxygenase activity and alter brain neurotransmitter levels. Life Sci 79 2269-2274. 

Oxidations by dioxygenases cw-hydroxylation of aromatic double bonds. Oxidations catalyzed by oxidases regio- and stereoselective oxidations of polyols oxidations of carbohydrates oxidations of hydroxy steroids oxidations of alkyl phenols to form chiral /7-hydroxybenzylic alcohols hydroxylation of phenols oxidation of amino acids to keto acids. 

In mice fed a tryptophan-deficient diet ad libitum for 1 week, Jones et al.31 reported on tissue serotonin synthesis rates, systemic tryptophan metabolism, and its response to steroid or cycloheximide treatment. In the experimental mice, brain serotonin synthesis was decreased while duodenal serotonin synthesis was increased following a tryptophan load. Liver total protein was depressed in experimental mice but increased following a tryptophan load. Blood tryptophan (total and free) and albumin were decreased in experimental mice, but ratios of albumin-bound tryptophan were increased. Enzyme kinetic studies indicated that, in experimental mice, brain tryptophan-5-hydroxylase had a reduced Vmax but the enzyme response to tryptophan or hydrocortisone injection was increased. However, hepatic tryptophan-2,3-dioxygenase response to tryptophan or hydrocortisone injection was blunted in experimental mice. 

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