Sterilization vapor-phase hydrogen-peroxide

Nakahira, K. Validation of deep vacuum vapor phase hydrogen peroxide sterilizer retrofit to a production lyophilizer. PDA Asian Symposium, p. 1/6-6/6, Tokyo 1994... 

VII. VALIDATION OF VAPOR PHASE HYDROGEN PEROXIDE STERILIZATION PROCESS... 

Vapor phase hydrogen peroxide equipment and process are described elsewhere [36]. The basic steps in the process are dehumidification, conditioning, sterilization, and aeration. More specifically, there are five steps that must be part of the validation protocol [36]. 

Freeze dryers are usually steam sterilized or sterilized using VPHP (vapor phase hydrogen peroxide). Trays used in a freeze dryer are usually cleaned and sterilized separately. 

Klapes, N.A. and Vesley, D. Vapor-phase hydrogen peroxide as a surface decontaminant and sterilant. Applied Environmental Microbiology 56 503-506,1990. 

Graham, G.S. (1992) Sterilization of isolators and lyophilizers with hydrogen peroxide in vapor phase. International Congress on Advances Technologies for Manufacturing of Aseptic and Therminally Sterilized Pharmaceuticals and Biopharmaceuticals, Basel, Switzerland. 

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