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Steric effect modeling

Segmental equation A steric effect model that separately parameterizes each segment of a substituent. It requires fewer parameters than the XB equation and is generally more effective than the SB equation. [Pg.729]

The quatemization reaction of the thiazole nitrogen has been used to evaluate the steric effect of substituents in heterocyclic compounds since thiazole and its alkyl derivatives are good models for such study. In fact, substituents in the 2- and 4-positions of the ring only interact through their steric effects (inductive and resonance effects were constant in the studied series). The thiazole ring is planar, and the geometries of the ground and transition states are identical. Finally, the 2- and 4-positions have been shown to be different (259. 260). [Pg.386]

The effect of the conformation of amic acid on the imidi2ation rate is also consistent with the observation that the thermal cycli2ation of model compounds, N-substituted phthalamic acids, is strongly influenced by the steric effect imposed by N-substituents (18). [Pg.399]

Examine space-filling models for the two conformers and identify any likely unfavorable nonbonded interactions. Based on steric effects, which conformer would you anticipate would be the more stable Compare energies of anti-1,2-ethanediol and gauche-1,2-ethanediol to see if you are correct. Is this the same ordering of conformer energies as seen for n-butane (see Chapter 5, Problem 3)7... [Pg.121]

Lim et al. also investigated HMTA-phenolic reactions with somewhat larger model compounds (e.g., two- and four-ring compounds) and established that similar reaction pathways to those described previously occurred.50 For these model compounds (as opposed to one-ring model compounds), which are more representative of typical oligomeric systems, increased molecular weight favored die formation of hydroxybenzylamines but not benzoxazines. This was suggested to be a steric effect. [Pg.398]

Solvolytic experiments specifically designed to test Bartell s theory were carried out by Karabatsos et al. (1967), who were primarily interested in an assessment of the relative contributions of hyperconjugation and non-bonded interactions to secondary kinetic isotope effects. Model calculations of the (steric) isotope effect in the reaction 2- 3 were performed, as well as that in the solvolyses of acetyl chloride... [Pg.16]

This difference between NHCs and phosphines was acknowledged early, and the so-called fence model, see Fig. 1.16, was proposed [79], In this model the NHC is seen as a fence , with a length and a height . These quantities were initially used to quantify the steric effect of NHCs. However, this model showed some limitations in properly capturing the behaviour of some common NHCs, such as ICy, and was thus abandoned [79]. [Pg.17]

If the substituents are nonpolar, such as an alkyl or aryl group, the control is exerted mainly by steric effects. In particular, for a-substituted aldehydes, the Felkin TS model can be taken as the starting point for analysis, in combination with the cyclic TS. (See Section 2.4.1.3, Part A to review the Felkin model.) The analysis and prediction of the direction of the preferred reaction depends on the same principles as for simple diastereoselectivity and are done by consideration of the attractive and repulsive interactions in the presumed TS. In the Felkin model for nucleophilic addition to carbonyl centers the larger a-substituent is aligned anti to the approaching enolate and yields the 3,4-syn product. If reaction occurs by an alternative approach, the stereochemistry is reversed, and this is called an anti-Felkin approach. [Pg.90]

A number of steric effects on the rate of rearrangement have been observed and can be accommodated by the chairlike TS model.242 The Zf-silyl ketene acetals... [Pg.568]

The addition reaction of allylsilane to acetaldehyde with BF3 as the Lewis acid has been modeled computationally.95 The lowest-energy TSs found, which are shown in Figure 9.2, were of the synclinal type, with dihedral angles near 60°. Although the structures are acyclic, there is an apparent electrostatic attraction between the fluorine and the silicon that imparts some cyclic character to the TS. Both anti and syn structures were of comparable energy for the model. However, steric effects that arise by replacement of hydrogen on silicon with methyl are likely to favor the anti TS. [Pg.817]

Another hypothesis was provided by Mikio Shimitso (1982) on the basis of studies of steric effects in molecular models. It had been noted years previously that the fourth nucleotide at the 3 end of the tRNA molecules (referred to as the discrimination base) might have a recognition function. In the case of certain amino acids (i.e., their tRNA-amino acid complexes) this base pair, in combination with the anticodon of the tRNA molecule, can select the amino acid corresponding to the tRNA species in question this is done on the basis of the stereochemical properties of the molecule. Since the anticodon of a tRNA molecule and the fourth nucleotide of the acceptor stem are far apart in space, two tRNA molecules must complex in a head-to-tail manner. The pocket thus formed can then fit specifically to the corresponding amino acid. [Pg.218]

The P-aryl phosphanorbomenes (85 and 104) prepared by us served as excellent model compounds in photoinduced fragmentation-related phosphorylations. On the one hand, new //-phosphinates (105) were synthesized (Scheme 27), while on the other hand, our experiments indicating a high sensitivity towards the steric effects substantiated the AE mechanism involving a pentacoordinated pentavalent intermediate (106) (Scheme 28) [74, 75],... [Pg.170]

The next two sections deal with physicochemical models for the thermochemical and electronic effects which are used in the evaluations. This work is fairly well progressed. However, there are other effects which we are fully aware influence reactivity appreciably, but which we have so far investigated to only a limited degree. These include solvent and steric effects. We refer to these topics only briefly later in this article. [Pg.41]

In the case of complexes such as (21) and (23) which have an extended planar ligand, a significantly higher proportion of interstrand cross-links in DNA is formed in comparison to either cis- or trans-platin.172 The steric effects of these planar ligands result in the formation of structurally unique 1,2-interstrand cross-links like those formed by cisplatin, a unique example of how steric effects may alter a nonactive lesion into an active one (Figure 13).173,174 Model studies predicted this outcome by preparation of the monofunctional models trans-[PtCl(9-ethylguanine) (NH3)(quinoline)] and comparison of substitution rates of the Pt—Cl bond by G or C mononucleotides.175 176 Interestingly, the iminoether compound (25) appears to form predominantly monofunctional adducts with DNA.177... [Pg.824]


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See also in sourсe #XX -- [ Pg.260 ]




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Monoparametric model of steric effects

Steric effects branching models

Steric effects composite model

Steric effects monoparametric model

Steric effects multiparametric models

Steric effects segmental model

Steric effects simple branching model

Steric model

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