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Stem cell therapy drug discovery

Shi, Y. 2009. Induced pluripotent stem cells, new tools for drug discovery and new hope for stem cell therapies. Curr Mol Pharmacol, 2,15-8. [Pg.661]

Human-derived cellular models hold promises in PD modeling and drug discovery. Development of culture systems based on dopaminergic neurons derived from patients with the familial or sporadic PD may enable the discovery of new neuroprotective candidates to work synergistically with currently approved pharmacological therapies. Initial work in this field includes the differentiation of human embryonic stem cells (hESCs) into neurons of dopaminergic identity [96]. [Pg.305]

Sutherland, M.L., Fabre, K.M., Tagle, D.A. (2013). The national institutes of health microphysiological systems program focuses on a critical challenge in the drug discovery pipeline. Stem Cell Research and Therapy, 4, 1-5. [Pg.26]

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