Stavudine dysfunction

Brivet FG, Nion I, Megarbane B, Slama A, Brivet M, Rustin P, Munnich A. Fatal lactic acidosis and liver steatosis associated with didanosine and stavudine treatment a respiratory chain dysfunction J Hepatol 2000 32(2) 364-5. 

Renal tubular dysfunction and hjrpophosphatemia occurred in a patient who was taking both stavudine and lamivudine (4). 

A Fanconi syndrome with nephrogenic diabetes insipidus was reported in a patient wifh AIDS who was receiving didanosine (and ofher medications) [115] and also in a patient treated with stavudine and lamivudine [116]. The metabolic acidosis in this case was partly due to lactic acidosis, perhaps related to mitochondrial dysfunction. Abacavir was recently implicated as a... 

The effect of stavudine-based HAART on mitochondrial respiratory transport chain function in CD4-I- peripheral blood lymphocytes has been studied in HTV-positive patients in Australia [73. CD4-I-lymphocytes isolated from asymptomatic stavudine-treated patients had reduced basal mitochondrial oxygen consumption compared with untreated HIV-infected patients and uninfected controls. Cells from the stavudine-treated patients also had reduced maximal oxygen consumption. There were no significant differences in citrate synthase activities, mitochondrial volume, or mitochondrial DNA copy numbers per cell between the groups. These findings support an association between stavudine and mitochondrial dysfunction and suggest that the alteration in function does not solely result from the... 

Friedhuber A, Wesselingh SL, Pepe S. Mitochondrial dysfunction in CD4+ lymphocytes from stavudine-treated HTV patients. Mitochondrion 2010 10(5) ... 

The lipoatrophy that has been associated with nucleoside reverse transcriptase inhibitors is accompanied by mitochondrial dysfunction, and in 10 patients who had taken stavudine, lamivudine, and lopinavir + ritonavir for over 6 years, mitochondrial function and morphology improved after switching from stavudine to tenofovir [60 ]. 

Acid-base balance A 42-year-old woman with advanced HIV disease who had taken stavudine, lamivudine, nevirapine, and prophylactic co-trimoxazole for 9 months developed a high anion gap metabolic acidosis with a pH of 7.15, due to lactic acidosis [114 ]. She was also discovered to have persistent glycosuria, phosphaturia, and aminoaciduria, in keeping with proximal renal tubular dysfunction. The lactic acidosis was attributed to the stavudine and the Fanconi syndrome to the combination of stavudine and lamivudine. 

---