Static stereoelectronics

This approach defines molecular conformation by utilizing stereoelectronic interactions that are not directly involved in the reaction. This control is often used efficiently for achieving selectivity in a chemical process by enforcing a desired geometry. 

This approach uses stereoelectronic effects to directly control the bond-forming and bond-breaking steps. It can lead to changes in reaction rates, chemo- and regioselectivities, as well as new reactivity patterns. 

The initial feature of this approach is the elegant double use of allylic A - strain (imposed by amide resonance at the two nitrogen atoms flanking the Cl carbon) to force the bulky tert-butyl group into the axial 

Stereoelectronic Ejfects A Bridge Between Structure and Reactivity, First Edition. Igor V. Alabugin. 2016 John Wiley Sons, Ltd. Published 2016 by John Wiley Sons, Ltd. 

Electrophile attacks from the bottom via an axial approach 

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Stability and reactivity of crown-ether complexes, 17, 279 Stereochemistry, static and dynamic, of alkyl and analogous groups, 25, 1 Stereoelectronic control, the principle of least nuclear motion and the theory of, 24, 113 Stereoselection in elementary steps of organic reactions, 6, 185 Steric isotope effects, experiments on the nature of, 10, 1... 

Stereochemistry, static and dynamic, of alkyl and analogous groups, 25, 1 Stereoelectronic control, the principle of... 

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