Standard uptake value

R.J. Downey, T. Akhurst, M. Gonen, A. Vincent, M.S. Bains, S. Larson, V. Rusch, Preoperative F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value predicts survival after lung cancer resection, J. Clin. Oncol. 22(16) (2004) 3255-3260. 

C.K. Kim, N.C. Gupta, B. Chandramouli, A. Alavi, Standardized uptake values of FDG Body surface area correction is preferable to body weight correction, J. Nucl. Med. 35(1) (1994) 164-167. 

K.R. Zasadny, R.L. Wahl, Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose Variations with body weight and a method for correction. Radiology 189(3) (1993) 847-850. 

Figure 9 Effect of cyclosporin A on the brain (A) and plasma (B) concentration of nC verapamil in healthy volunteers. (A) 1 -Verapamil ( 0.2 mCi/kg) was administered to healthy volunteers intravenously, approximately one minute before and after one-hour infusion of cyclosporin A (2.5 mg/kg/h). (B) PET images of a normal human brain after nC-verapamil administration in the absence or presence of cyclosporin A. Images shown are in SUV summed over a period of 5 to 25 minutes, which is an index of regional radioactivity uptake normalized to the administered dose and weight of the subject. Abbreviations PET, positron emission tomography SUV, standardized uptake value. Source From Ref. 218.

The most versatile semiquantitative technique is the standard uptake value (SUV) method that is widely used in nuclear medicine and molecular imaging. This value is also less commonly referred to as the differential uptake ratio (DUR). ft is dehned by the tissue concentration of activity as determined from the region of interest (ROI) on the PET image, divided by the injected dosage of the tracer, and multiplied by a calibration factor, which is basically the body weight, body surface or body lean mass. Thus,... 

Because of its high sensitivity in detecting malignant lesions and high negative predictive value PET has already established its role in initial staging and monitoring of therapy response for various cancers. False positive results have been described in inflammatory disease [38] since FDG uptake is not cancer specific. The standardized uptake value (SUV) pro-... 

Fig.8.10a,b. Correlation between FDG utilization (standardized uptake value, SUV) and MAA uptake. No correlation between metabolism and SIR-Spheres distribution can be shown, most probably due to the inclusion of tumor entities with different uptake behavior in F-FDG-PET (a). Analyses of several lesions in the same patient, by contrast, do reveal a relation between SUV and MAA in many instances as shown for a few patients in (b)... 

First study results indicate that a fusion of both modalities (PET and CT) improves diagnostic accuracy as well as lesion localization and report promising results for the staging of different oncological diseases compared to PET and CT alone [21,32]. The total standard uptake value (SUV) of the entire axial slices of the liver as well as of the individual lesion... 

Image evaluation of PET is performed both qualitatively and quantitatively. The reader assesses the PET data for regions of focally increased tracer uptake (qualitative image analysis). A region of interest is drawn around a hot spot on PET, offering quantitative analysis of the tracer activity in that area. Quantitative PET data are typically reported as standardized uptake values (SUV) ... 

Figure 3.5 PET imaging of a patient with histologically confirmed progressive prostate cancer that was monitored for response to high dose testosterone treatment using F-FDHT. The top shows transaxial and coronal images of F-FDHT uptake in three lesions prior to testosterone treatment. The bottom shows time-activity curves [activity presented as the normalized standard uptake value (SUV)] for the average of the three lesions pre- (dashed line) and posttreatment (solid line). This study demonstrates the ability to image the intracellular androgen receptor, how PET can be used to monitor therapy, and PET s ability to quantify results. Reproduced with permission from Ref. (50).

Fig. 5 Standardized uptake value (SUV) of Ga-DOTA-Labeled glycoclusters 5a, 6a, and 7a-c in normal BALB/c nude mice. SUV was normalized by radioactivity in the tissue region, injected dose, and weight of the subjects. These values represent the means and S.Ds...

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