Sponges spongouridine

C9H12N206. also known as spongouridine. were first isolated from the sponge C. crypta. 

Cytosine arabinoside (69), a synthetic analog of the C-nucleosides spongouridine (70) and spongothymidine (71) from the sea sponge Cryptotheca cripta, was the first and, so far, the only marine-derived compound used routinely as an anticancer agent (110). However, a number of chemically diverse natural products from marine sources have been progressed to clinical trials. The three most advanced compounds are in phase II trials ecteinascidin-743 (72), a tetrahydroisoquino-... 

Marine life can also be a rich source of medicinal material. For example, C-nucleosides spongouridine and spongothymidine isolated from the Caribbean sponge Cryptotheca crypta possess antiviral activity. Synthetic analogues led to the development of cytosine arabinoside, a useful anticancer drug. Microbes also provide extremely useful medicines, the most famous case being penicillin... 

Arabinosylpyrimidine Nucleosides. 1-p-D-Arabinofuranosylthymine [605-25-2] (ara-T) (174), C10H14N2O6, and 1-p-D-arabinofiiranosyluracil [5085-77-0] (ara-U) (175), also known as spongouridine, were first isolated from the sponge C. crypta (1—4). The... 

Bergmann, W. and Burke, D.C. (1955) Contributions to the study of marine products. XXXIX. The nucleosides of sponges. III. Spongothymidine and spongouridine./. Org. Chem., 20, 1501-1507. 

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