Spinal cord, capsaicin effects

Marks IM, Stern RS, Mawson D, et al Clomipramine and exposure for obsessive compulsive rituals. Br J Psychiatry 136 1-25, 1980 Marley PD, Nagy Jl, Emson PC, et al Cholecystokinin in the rat spinal cord distribution and lack of effect of neonatal capsaicin treatment and rhizotomy. Brain Res 238 494-498, 1982... 

The most important adverse effect of capsaicin is the initial burning sensation that it produces. Intravesical capsaicin induces intense suprapubic pain during intravesical instillation that may be made tolerable by lidocaine in some but not all patients. Capsaicin also frequently causes a transient worsening of the urinary conditions before improvement of symptoms due to desensitization of bladder afferents becoming evident. In patients with high spinal cord lesions capsaicin might provoke life-threatening autonomic dysreflexia. 

Unlike capsaicin it not only suppresses chemogenic pain, but is effective against noxious heat-evoked pain in normal rats as well as cold-evoked pain in animals with spinal cord injury. 

Abrahamsson C (2000) Neuropeptide Y1- and Y2-receptor-mediated cardiovascular effects in the anaesthetized guinea pig, rat, and rabbit. J Cardiovasc Pharmacol 36 451-8 Ackley MA, Hurley RW, Virnich DE et al (2001) A cellular mechanism for the antinociceptive effect of a kappa opioid receptor agonist. Pain 91 377-88 Aimone LD, Yaksh TL (1989) Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo. Peptides 10 1127-31... 

Dirig DM, Yaksh TL (1995) Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formahn model. J Pharmacol Exp Ther 275 219-227 Dirig DM, Yaksh TL (1999) In vitro prostanoid release from spinal cord following peripheral inflammaton effects of substance P, NMDA and capsaicin. Br J Pharmacol 126 1333-1340... 

Kirby, M.L., Gale, T.F., and Mattio, T.G., Effects of prenatal capsaicin treatment on fetal spontaneous activity, opiate receptor binding, and acid phosphatase in the spinal cord, Exp. Neurol, 76,298-308, 1982. 

Administration of high doses of capsaicin to the rat by the subcutaneous route was the first procedure by which an effect on spinal cord substance P was found. It is noteworthy that this work, conducted by Gasparovic et al. (1964), preceded by many years the current surge of interest in capsaicin. Using a bioassay for substance P, they showed that capsaicin reduced the content of this peptide in whole spinal cord but did not alter that of whole brain. This has recently been confirmed by Jessell et al. (1978) who, using radioimmunoassay techniques, found a 48% reduction in the levels of spinal cord dorsal horn substance P. Similar results have since been obtained by Gamse et al. (1980a,fe). In addition they reported reduced substance P content of dorsal roots, dorsal root... 

Lawson, S. N., 1981, Dorsal root ganglion neurons and dorsal roots effect of neonatal capsaicin, in Spinal Cord Sensation Sensory Processing in the Dorsal Horn, (A. G. Brown, ed.), pp. 67-71, Scottish Press, Edinburgh. 

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