Sphingosine-1-phosphate signaling

Pyne S, Pyne NJ 2000 Sphingosine 1-phosphate signalling in mammalian cells. Biochem J 349 385M02... 

Pyne, S. and Pyne, N.J., 2000, Sphingosine 1-phosphate signaling in mammalian cells, Biochem. J. 349 385 2. 

Zondag, G.C., Postma, F.R., Van Etten, A., Verlaan, I. and Moolenaar, W.H., 1998, Sphingosine 1-phosphate signaling through the G-protein-coupled receptor Edg-1. Biochem. J. 330 605-609. 

Peters SLM, Alewijnse AE. Sphingosine-1-phosphate signaling in the cardiovascnlar system. Cnrr. Opin. Pharmacol. 2007 7 186-192. 

J (2001) Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in... 

Ishii, I., Friedman, B., Ye, X., Kawamura, S., McGiffert, C., Contos, J. J., Kingsbury, M. A., Zhang, G., Brown, J. H., Chun, J. Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem 276 (2001) 33697-33704. 

Tamama, K., Okajima, F. 2002. Sphingosine 1-phosphate signaling in atherosclerosis and vascular biology. Curr. Opin. Lipidol. 13 489-495. 

Argraves, K.M., Wilkerson, B.A., Argraves, W.S., Fleming, P.A., Obeid, L.M., and Drake, C.J. Sphingosine-l-phosphate signaling promotes critical migratory events in vasculogenesis. J Biol Chem, 279,2004, 50580-50590. 

G-protein-coupled receptors (GPCRs), although some of them additionally play a role in intracellular signal transduction. Sphingosine-1-phosphate (SIP) and... 

Most GPCRs interact with and activate more than one G-protein subfamily, e.g., with Gs plus Gq/n (histamine H2, parathyroid hormone and calcitonin recqrtors), Gs plus G (luteinising hormone receptor, 32-adrenoceptor) or Gq/11 plus G12/13 (thromboxane A2, angiotensin ATb endothelin ETA receptors). Some receptors show even broader G-protein coupling, e.g., to Gi, Gq/n plus Gi n ( protease-activated receptors, lysophosphatidate and sphingosine-1-phosphate receptors) or even to all four G-protein subfamilies (thyrotropin receptor). This multiple coupling results in multiple signaling via different pathways and in a concerted reaction of the cell to the stimulus. 

An, S., Bleu, T. and Zheng, Y., 1999, Transduction of intracellular calcium signals through G protein- mediated activation ofphosphohpase C by recombinant sphingosine 1- phosphate receptors. Mol. Pharmacol. 55 787-794. 

An, S., Goetzl, E.J. and Lee, H., 1998, Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. 

Durieux, M.E., Carlisle, S.J., Salafranca, M.N. and Lynch, K.R., 1993, Responses to sphingosine-1 -phosphate in X. laevis oocytes Similarities with lysophosphatidic add signaling. Am. J. Physiol. 264 C1360-C1364. 

Sillard, R., Harii, K. and Takuwa, Y., 1999, The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signaling pathways. Biochem. J. 337 67-75. 

Ishizuka, T., Murata, N., Kanda, T., Kobayashi, I., Ohta, H., Ui, M. and Okajima, F., 1999, Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor sub-types to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells. J. Biol. Chem. 274 23940-23947. 

Tolan, D., Conway, A-M., Rakhit, S., Pyne, N.J. and Pyne, S., 1999, Assessment ofthe extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model. Cell. Signal. 11 349-354. 

Igarashi, Y. Functional roles of sphingosine, sphingosine 1-phosphate, and methylsphingosines in regard to membrane sphingolipid signaling pathways (1997) I Biochem. (Tokyo) 122, 1080-7... 

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