Spectra charcoal

Sodium p-toluenesulfinate [824-79-3] M 178.2, pK 2.80 (1.99)(for -S02 ). Crystd from water (to constant UV spectrum), and dried under vacuum or extracted with hot benzene, then dissolved in EtOH-H20 and heated with decolorising charcoal. The solution was filtered and cooled to give crystals of the dihydrate. 

B. Hydrogenolysis of the Phenolic Ether Biphenyl. To a solution of 10 g. (0.032 mole) of the product from Part A in 200 ml. of benzene is added 2 g. of 5% palladium-on-charcoal, and the mixture is shaken with hydrogen in a Parr apparatus at 40 p.s.i. and 35-40° for 8 hours (Note 3). The mixture is filtered, and the insoluble residue is washed with three 100-ml. portions of hot ethanol (Note 4). The filtrates are combined, and the solvent is removed by means of a rotary evaporator at 60° (12 mm.) to leave a solid residue. The product is dissolved in 100 ml. of benzene, and 100 ml. of 10% sodium hydroxide solution is added. The mixture is shaken, and the layers are separated. The aqueous layer is extracted with 100 ml. of benzene, and the original benzene layer is washed with 100 ml. of water (Note 5). The benzene solutions are combined and dried over magnesium sulfate. Removal of the benzene by distillation yields 4.0-4.7 g. (82-96%) of biphenyl as a white powder, m.p. 68-70° (Note 6). The infrared spectrum is identical with that of an authentic sample, and a purity of at least 99.5% was indicated by gas chromatography analysis. 

PCN-sensitive staph) Action Bact icidal -1- cell wall synth Spectrum Most gram(+), including str Dose Adults. 250-500 mg PO q6h, q8h, q 12h Peds. 25-50 mg/kg/25h PO in 4 doses -1- in renal impair on empty stomach Caution [B, M] Contra Allergy Disp Tabs, susp SE GI upset, int stitial nephritis, anaphylaxis, convulsions Interactions -1- Effects W/ ASA, probenecid t effects OF MTX t risk of anaphylaxes W/BB -1- effects W/ chloramphenicol, macrolides, tetracyclines X effects OF OCPs EMS Monitor for sup Infxn T effects of anticoagulants monitor for signs of electrol5rte disturbances and h5 povolemia d/t D OD May cause N/D and Szs activated charcoal may be effective... 

Benzidine [92-87-5] M 184.2, m 128-129 . Its soln in benzene was decolorized by percolation through two 2-cm columns of activated alumina, then concentrated until benzidine crystd on cooling. Recrystd alternatively from EtOH and benzene to constant absorption spectrum [Carlin, Nelb and Odioso JACS 73 1002 7957]. Has also been crystd from hot water (charcoal) and from ethyl ether. Dried under vac in an Abderhalden pistol. Stored in the dark in a stoppered container. CARCINOGENIC. 

Figure 10.18—Photoacoustic detection device. The spectrum is obtained in the photoacoustic units PAS = 100/s//rcf (where 7S is the sample signal intensity and /ref is the reference intensity). The reference consists of activated charcoal. The spectrum resembles an absorption spectrum.

A solution of 17 g (0.1 mole) of 3-(4-hydroxyphenyl)propionic acid in 500 mL methanol and 2 mL concentrated sulfuric acid were placed in a Soxhlet extractor charged with 3A molecular sieves. The solution was refluxed for 72 hours and the sieve were exchanged at 24 hour intervals. The reaction medium was then evaporated to an oil which was dissolved in 100 mL toluene and extracted with 100 mL water (3 times). The toluene phase was dried over magnesium sulfate, treated with activated charcoal and evaporated to provide 15 g (80%) of a clear oil. The NMR spectrum was consistent with the methyl 3-(4-hydroxyphenyl)propionate. 

Huvenne and Lacroix described a mathematical procedure for the correlation of band intensities of the Fourier-transform infrared absorption spectra with those of the corresponding infrared transmission spectra of compounds in KBr discs [22]. The procedure was applied to spectra of flunitrazepam, dipyridamole, and lactose that were obtained through the use of a Nicolet 7199 B FTIR spectrometer with photoacoustic detection. When the photoacoustic spectrum of a plant charcoal was used to correct the spectra for inequalities in the incident light flux before applying the procedure, the correlated band intensities were generally consistent with those obtained using infrared transmission spectra. The procedure may be useful for the direct identification of the drugs. 

Another example in the C-glycosylated, unsaturated hydrocarbon series is methyl 2-deoxy-3,4-0-isopropylidene-2-C-methylene-/3-D-erythro-pentopyranoside (213), obtained90 in 55% yield by the reaction of methyl 3,4-0-isopropylidene-/3-D-eryfhro-pentopyranosid-2-ulose (212) with methylenetriphenylphosphorane n-butyllithium was used as a proton acceptor. Subsequent reduction of 213 with 10% palladium-on-charcoal led to a 7 1 mixture of the 2-epimeric methyl 2-deoxy-2-C-methylpentopyranosides (214 and 215, respectively). In the n.m.r. spectrum of 214, the H-l resonance appeared as a doublet at r 5.62 p.p.m., exhibiting aJia coupling constant of 8 Hz, thus indicating H-2 to be axial and, therefore, the D con-... 

Dehydrogenation of cinchonamine with selenium or palladium-charcoal resulted in fission of the quinuclidine ring and the isolation of dehydrocinchonamine (V), mp 203°, whose spectral characteristics and p/fa were in agreement with its formulation. From the selenium dehydrogenation products, a trace of a crystalline compound was also obtained which, from a single ultimate analysis and UV-spectrum, is considered to be IV (10). 

If a catalyst mass contains only one type of catalytic site we shall call it a monofunctional catalyst. By one type is meant that every catalytic site or surface exhibits the same qualitative catalytic property as to what reaction or reaction steps it can catalyze. We shall concern ourselves only, of course, with reaction steps which are thought to be relevant to the reaction examined. For example, we normally assume that platinum/charcoal is a monofunctional catalyst in the hydrogenation of olefins. (For the present purpose we need not be concerned about the quantitative equivalence of every Pt-surface site, i.e., whether or not there is uniformity or a spectrum of catalytic effectiveness for the same reaction among different platinum sites.)... 

Dehydrogenation of himbacine with palladium-charcoal at 260° furnished dehydrohimbacine (V). That the transformation involved the saturation of the double bond and the conversion of an A -methyl-piperidine system into a pyridine derivative was apparent from the elemental analysis of the product, its UV-spectrum 265 mp, log 3.65), and the marked change in p/v from 9.3 to 5.4 (50% ethanol). Compound V was also obtained from dihydrohimbacine under the same conditions. 

Uyeo and co-workers provided independent confirmation of these two structural possibilities (6). They found that tuberostemonane, an important product from the dehydrogenation (Pd, charcoal) of tubero-stemonine, had a U V-absorption spectrum similar to that of indole. When oxidized with chromic acid it gave a product having an isatin-like absorption spectrum. 

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