Species differences in response

Green T, Prout MS. 1985. Species differences in response to trichloroethylene. 11. Biotransformation in rats and mice. Toxicol Appl Pharmacol 79 401-411. 

Fig. 7.7 Discrimination by F. (a) of estrous, vs. non-estrous, urine frequency in feral goats (from O Brien, 1982) and (b) within social groups, species-differences in responsiveness of male antelopes to urinary and/or genital signals (from Hart and Hart, 1987).

Cornu MC, Lhuguenot JC, Brady AM, et al. 1992. Identification of the proximate peroxisome proliferators derived from di(2-ethylhexyl) adipate and species differences in response. Biochem Pharmacol 43 2129-2134. 

Weisburger EK. 1983. Species differences in response to aromatic amines. Basic Life Sci 27 23-47. 

Weisburger EK. 1983. Species differences in response to aromatic amines. Basic Life Sci 27 23-47. Werner R. Uehleke H, Wohrlin R. 1976. Reduction of azobenzene to hydrazobenzene by liver fractions. Naumyn-Schmeidebergs Arch Pharmacol 293 54. 

Elcombe, C.R., Bell, D.R., Elias, E., Hasmall, S.C. Plant, N.J. (1996) Peroxisome proli-ferators Species differences in response of primary hepatocyte cultnres. Ann. N.Y. Acad. Sci., 804, 628-635... 

Tugwood, J.D., Holden, P.R., James, N.H., Prince, R.A. Roberts, R.A. (1998) A peroxisome proliferator-activated receptor-alpha (PPARa) cDNA cloned from guinea-pig liver encodes a protein with similar properties to the mouse PPARa implications for species differences in responses to peroxisome proliferators. Arch. Toxicol., 72, 169-177 Turner, J.H., Petricciani, J.C., Crouch, M.L. Wenger, S. (1974) An evaluation of the effects of diethylhexyl phthalate (DEHP) on mitotically capable cells in blood packs. Transfusion, 14, 560-566... 

Woodyatt, N.J., Lambe, K.G, Myers, K.A., Tugwood, J.D. Roberts, R.A. (1999) The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population significance for species differences in response to PPs. Carcinogenesis, 20, 369-372... 

Hasmall SC, James NH, Macdonald N, et al. 2000. Species differences in response to diethylhexylphthalate suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression. Arch Toxicol 74 85-91. 

Trichothecene toxicosis is manifested by a broad spectrum of clinical disorders, which vary according to the specific causative toxin or mixture of toxins. Species differences in response are generally related to severity of the response, and young animals are more susceptible than adults. Toxicosis can be acute or chronic, with clinical signs remaining fairly similar. A comprehensive review of the pathophysiology of spontaneous and experimentally induced trichothecene mycotoxicosis is available (Beasley, 1989). 

Species differ in responses to TOCP. The chicken and cat have been used extensively especially because the responses in those species are very similar to those of man. Rabbit, dog, monkey, and guinea pig react inconsistently while rats and mice are reported to be resistant to paralysis although they still have nervous tissue damage. 

Green, T., Toghill, A., Lee, R., Waechter, F., Weber, E., Peffer, R., Noakes, J., and Robinson, M. (2005). Thiamethoxam induced mouse fiver tumors and their relevance to humans. Part 2 Species differences in response. Toxicol Sci 86, 48-55. 

James, N. H., and Roberts, R. A. (1996). Species differences in response to peroxisome proliferators correlate in vitro with induction of DN A synthesis rather than suppression of apoptosis. Carcinogenesis... 

TABLE 17.3. Species Differences in Responses to PPARa Activators... 

Strain and species differences in response to nitrobenzene exposure were demonstrated by Medinsky and Irons (1985). At an exposure level of 125 ppm nitrobenzene, there was a 40% rate of lethality in Sprague-Dawley (CD) rats and morbidity necessitating early sacrifice of all B6C3F1 mice. Fischer-344 rats, however, tolerated this level for 2 weeks without any adverse clinical signs. The relevance of these findings to human exposure is not known. 

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