Sparfloxacin Foods

SPARFLOXACIN Sparfloxacin may be taken with or without food. 

Sparfloxacin - Sparfloxacin is well absorbed following oral administration. Steady-state concentration was achieved on the first day by giving a loading dose that was double the daily dose. Oral absorption of sparfloxacin is unaffected by administration with milk or food, including high-fat meals. Sparfloxacin distributed well into the body. It penetrates well into body fluids and tissues. Sparfloxacin is metabolized by the liver. It is excreted in the feces (50%) and urine (50%). 

ABSORPTION, FATE, AND EXCRETION The quinolones are weU absorbed after oral administration and are widely distributed. Peak serum levels of the fluoroquinolones occur within 1-3 hours of an oral dose of 400 mg. Relatively low serum levels are reached with norfloxacin and limit its usefulness to the treatment of urinary tract infections. Food does not impair oral absorption but may delay the time to peak serum concentrations. Oral doses in adults are 200-400 mg every 12 hours for ofloxacin, 400 mg every 12 hours for norfloxacin and pefloxacin, and 250-750 mg every 12 hours for ciprofloxacin. Bioavailabrlity of the fluoroquinolones exceeds 50% for all agents and 95% for several. The serum half-lives range from 3 to 5 hours for norfloxacin and ciprofloxacin to 20 hours for sparfloxacin. The volume of distribution of quinolones is high, with concentrations in urine, kidney, lung and prostate tissue, stool, bUe, and macrophages and neutrophils higher than serum levels. Quinolone concentrations in CSF, bone, and prostatic fluid are lower than in serum. Pefloxacin and ofloxacin levels in ascites fluid approach serum levels, and ciprofloxacin, ofloxacin, and pefloxacin have been detected in human breast milk. 

Apart from dairy products (p.332), most foods delay but do not reduce the absorption of ciprofloxacin, enoxacin, gemifloxacin, lomefloxacin, ofloxacin or sparfloxacin. A high-fat/high-calcium breakfast did not reduce ciprofloxacin levels. Calcium-fortified orange juice significantly reduces the absorption of ciprofloxacin, but not gatifloxacin or levofloxacin. 

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