Sparfloxacin assay

Note 9 The authors mentioned that sparfloxacin, grepafloxacin, moxifloxacin, and ciprofloxacin (3, 10, 30, and 100 pg/ml) prolonged AP duration in a concentration-dependent manner. The assay is useful for certain compounds, which specifically decrease the conduction velocity of purkinje fiber (K-strophanthin in canine purkinje fiber). 

Marona H, Schapoval E. Development of a microbiological assay for the determination of sparfloxacin in powder and tablets. Inf Technol 1998 9 251-4. 

Marona H, Schapoval E. A high-performance liquid chromatographic assay for sparfloxacin. J Pharm Biomed Anal 1999 20 413-7. 

Lyon, D.J. Cheung, S.W. Chan, C.Y. Cheng, A.F. Rapid HPLC assay of clinafloxacin, fleroxacin, levo-floxacin, sparfloxacin and tosufloxacin. J.Antimicrob.Chemother., 1994, 34, 446-448 Mueller, B.A. Brierton, D.G. Abel, S.R. Bowman, L. Effect of feeding with Ensure on oral bioavailabilities of ofloxacin and ciprofloxacin. Antimicrob.Agents Chemother., 1994,38, 2101—2105 [extracted ciprofloxacin plasma ultrafiltration fluorescence detection A-57084 (IS) LOQ 9.5 ng/mL pharmacokinetics]... 

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