Sparce matrices

Efficient methods for solving large sets of linear equations, for example, the linearized constraints, particularly involving sparce matrices. 

Sage E Regulation of interactions between cells and extracellular matrix a command performance on several stages. J Clin Invest 2001 107 781. (This article introduces a series of six articles on cell-matrix interaction. The topics covered are cell adhesion and de-adhesion, thrombospondins, syndecans, SPARC, osteopontin, and Ehlers-Danlos syndrome. All of the articles can be accessed at www.jci.org.)... 

Puolakkainen P, Bradshaw AD, Kyriakides TR, Reed M, Brekken R, Wight T, Bomstein P, Ratner B, Sage EH. Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials. American Journal of Pathology 2003,162, 627-635. 

Kamihagi K, Katayama M, Ouchi R, et al. Osteonectin/SPARC regulates cellular secretion rates of fibronectin and laminin extracellular matrix proteins. Biochem Biophys Res Commun. 1994 200 423-428. 

Secreted protein, acidic and rich in cysteine (SPARC) is a multifunctional glycoprotein found within the extracellular matrix in a variety of tissues. It was found to be consistently upregulated in microarray analyses of tissue from scleroderma patients, and three new SNPs were found by sequencing the gene in... 

A second category of NCPs with Ca-binding properties is classified as mineraUzed tissue specific, since they are found in all the calcified connective tissues, namely, dentin, bone, and cementum. These proteins include osteocalcin (OC) and bone sialoprotein (BSP). A serine-rich phosphoprotein called dentin matrix protein 1 (Dmp-1), whose expression was first described as being restricted to odontoblasts [5], was later shown to be expressed by osteoblasts and cementoblasts [6]. Other NCPs include osteopontin and osteonectin [secreted protein acidic and rich in cysteine (SPARC)]. The fourth category of dentin NCPs is not expressed in odontoblasts but is primarily synthesized in the liver and released... 

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