SPARC software

Mobile phase ethanol/buffer 75/25% v/v pH 4 with 10 mM trietylamine + acetic acid n solute refractive index calculated using the SPARC software (http //ibmlc2.chem.uga.edu/sparc). 

NOESY was performed at 32 °C on a VXR-500 spectrometer operating at a proton frequency of 500 MHz. The protein was dissolved in 20 mM sodium phosphate, pH 7.5 (direct pH meter reading), 100 mM NaCl, 5 mM DTT in D2O. The protein concentration was 2 mM. The data was acquired in the hypercomplex mode with a mixing time of 150 ms (Jeener et al., 1979 Macura Ernst,1980). The spectral width was 7200 Hz in both dimensions. 2048 complex points in the t2 dimension and 256 complex points in the tl dimension were acquired. 96 transients were collected for each FID. Data processing was performed on a Sun Sparc 10 station using VNMR software from Varian. The time domain data were zero-filled once and multiplied by shifted sinebell or Gaussian functions before Fourier transformation in both dimensions. Chemical shifts were referenced to internal sodium 3-(trimethylsilyl)-propionate-2,2,3,3-d4. 

The pKa of a compound may be estimated using ACDpKa software, which also contains a large database of measured pKa data. The use of the computer program SPARC (scalable processor architecture) for estimating the pKa of pharmaceuticals has been described by Hilal etal. (1996). 

Versions of J for OS/2, Apple, Next, PC, Windows, Sparc, and many other platforms are available via anonymous ftp from watservl.uwaterloo.ca in languages/apl/j7exec. C source code is also available. See also K. Iverson, J Introduction and Dictionary (Toronto Iverson Software, 1993), The publisher s address is 33 Major Street, Toronto, Ontario MSS 2K9 Canada. 

The CLARISSE System and Software Development Environment (CLARISSE SSDE) are available for the specification, design, coding, and validation of l C systems. It runs on a UNIX based workstation (typically a Sun SPARC station under OS Solaris). ITie CLARISSE SSDE provides the followings functions ... 

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