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Sorbitol methylparabens

Methylparaben, Propylparaben preservative magnesium trisilicate, talc, tragacanth, sodium alginate, essential oils, sorbitol and atropine, yellow iron oxide, and ultramarine blue... [Pg.170]

Parabens are approved for use in oral solution and suspensions at a concentration of 0.015% to 0.2% w/v. Due to their low solubility, the sodium salts of parabens are often used in aqueous formulations. The parabens are most effective in the pH range of 2 to 6, and their antimicrobial activity decreases with increasing pH. Additionally, they are very unstable at pH 8 or above in solution. Methyl paraben has also demonstrated incompatibility with sorbitol and may show some discoloration in the presence of iron. The absorption of methylparaben by plastics has been reported with the amount absorbed being dependent upon the type of plastic and vehicle. However, no absorption has been reported for low density polyethylene (LDPE) or high density polyethylene (HDPE) containers. Certain coloring agents such as yellow iron oxide, ultramarine blue, and aluminum silicate can extensively absorb ethyl paraben in simple aqueous systems, thus reducing its preservative efficacy. [Pg.171]


See other pages where Sorbitol methylparabens is mentioned: [Pg.61]    [Pg.116]    [Pg.159]    [Pg.205]    [Pg.31]    [Pg.56]    [Pg.58]    [Pg.61]    [Pg.141]    [Pg.126]   
See also in sourсe #XX -- [ Pg.468 ]




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