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Somatostatin, recombinant

The advantages of recombinant DNA technology are enormous, as the following example shows. Somatostatin is a hormone that inhibits the secretion of pituitary growth hormone. The researchers who first isolated somatostatin required nearly half a million sheep brairrs to produce 5 mg of the substance. Using a chemically synthesized gene, 9... [Pg.453]

Genentech, Inc., repotted the production of the first human protein manufactured in a bacteria somatostatin, a human growth hormone-releasing inhibitory factor. For the first time, a synthetic, recombinant gene was used to clone a protein. Many consider this to be the advent of the Age of Biotechnology. [Pg.212]

DNA recombination, i.e. bacterial production of peptide hormones, e.g, insulin, somatostatin, or GRF (growth-hormone-releasing factor)17> 18. ... [Pg.113]

Reisine T, Bell GI (1995) Molecular biology of somatostatin receptors. Endocrine Reviews 16 427 Trainer PJ, Holly J, Medbak S, Rees LH, Besser GM (1994) The effect of recombinant IGF-I on anterior pituitary function in healthy volunteers. Clin Endocrinol (Oxf) 41 801 Tucker MJ (1999) Pituitary Toxicology Direct Toxicity, Secondary Changes and Effects on Distal Target Tissues. In Harvey PW, Rush KC, Cockburn A (eds) Endocrine and Hormonal Toxicology. John Wiley Sons, England, pp 15-32... [Pg.357]

Fig. 24.9 Production of recombinant somatostatin. The small size of somatostatin allows the chemical synthesis of the gene coding for it. This gene can be cloned into an expression fused to [i-galactosidasc. The fusion protein generated in E. coli is then purified and the somatostatin polypeptide is released by treatment with cyanogen bromide. Fig. 24.9 Production of recombinant somatostatin. The small size of somatostatin allows the chemical synthesis of the gene coding for it. This gene can be cloned into an expression fused to [i-galactosidasc. The fusion protein generated in E. coli is then purified and the somatostatin polypeptide is released by treatment with cyanogen bromide.
Dimech, J. et al. (1993) Antagonist effects of seglitide (MK 678) at somatostatin receptors in guinea-pig isolated right atria. Br. J. Pharmacol.. 109.898-899. Wilkinson. G.F. et al. (1996) Potent antagonism by BlM-23056 at the human recombinant somatostatin ssts receptor. Br.J. Pharmacol.. 118, 445-447. Alexander. S.P.H. et al. (1998) Receptors and ion channel nomenclature supplement. Ninth Edition. Trends Pharmacol. Set.. Suppl., 19,1-98. [Pg.260]

Castro SW, Buell G, Feniuk W, Humphrey PP (1996) Differences in the operational characteristics of the human recombinant somatostatin receptor types, sstl and sst2, in mouse fibroblast Ltk . cells. Br J Pharmacol 117 639-646... [Pg.94]

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