Solvents resource usage

No matter where recycling occurs, either in-process or out-of-process, the total mass metric will necessarily be reduced by the amount of recycled materials in the process. It is therefore important not only to account for the reduced impacts from a life cycle viewpoint, but also to account for the environmental and resource usage impacts that result from recycling materials (e.g., distillation energy for solvent recovery). It should be noted that in most cases the benefits associated with the avoidance of manufacturing impacts tend to dwarf the energy and resources requirements for recycling the materials. 

In order to solve analytical problems for a particular compound or class of compounds, as well as to save time and resources, it is essential that systematic method development concepts are applied. Such methods then enable a successful scaling up to preparative purifications as well as the design and application of MD-HPLC purification schemes. Moreover, if used in conjunction with dereplication procedures, these advances in high-resolution chromatographic methods may lead to new discoveries that can be used to advance science or medicine and at the same time respect the environment through reduced solvent and reagent usage. 

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