Solvent-Free C-O Bond Formation under Photoirradiation

5 g of ground halogenocarboxylate 1 is heated in an open round-bottom flask in an oil bath. Heating to the reaction temperatures should occur carefully otherwise, decomposition and combustion may occur. Reaction conditions sodium 2-chloropropionate 1 30 min at 160 °C sodium 3-chloropropionate 2 45 min at 120 °C sodium 2-chlorobutyrate 3 30 min at 160 °C. The reaction mixture becomes liquid during the reaction. After reaction is complete, a viscous brown-yellow oil remains. The organic pail of the reaction mixture is extracted with CHCI3, and the undissolved NaCl is filtered off. Removal of CHCI3 in vacuo leaves a viscous yellow oil. 

2 Solvent-Free C-O Bond Formation under Photoirradiation 

Type of reaction C-O bond formation Reaction condition solid-state 

Keywords nitrone, photocyclization, inclusion complex, oxaziridine 

The 1 1 inclusion complex of (-)-l and 2a was powdered and irradiated by a high pressure Hg-lamp for 24 h at room temperature, and tlie reaction mixture was cliromatographed on silica gel (benzene) to give (+)-3 in 56% yield. 

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Solvent-Free C—O Bond Formation under Photoirradiation 295... 

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See also in sourсe #XX -- [ , ]

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