Solvent-Free C-O Bond Formation

Keywords phenol, carboxylic acid, P205/Si02, ester 

A mixture of 1.42 g (0.01 mol) phosphorus pentoxide and 2.5 g of clu omatogra-phy grade silica gel was placed in a flask and stirred for 30 min. A mixture of equimolar amounts (5 mmol) of the carboxylic acid and phenol was added. Usually an immediate color change was observed. After stirring for 6 h at the temperature indicated in the Table, methylene chloride (50 mL) was added. The mixture was stirred for 1 min and then filtered. The spent reagent was washed twice with metiiylene chloride (10 mL). The combined organics were washed with aqueous NaOH solution, water and dried over sodium sulfate, and tlie solvent was removed under reduced pressure. 

References H. Eshghi, M. Rafei, M. H. Karimi, Synth. Commun., 31, 771 (2001). 

Solvent-free organic Synthesis. Kiochi Tanaka 

Copyright 2003 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 3-527-30612-9 

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Solvent-Free C-O Bond Formation under Photoirradiation 309... 

Solvent-Free C—O Bond Formation under Photoirradiation 295... 

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