Solids, supramolecular synthesis structural

It has already been shown that it is possible to develop practical strategies for supramolecular synthesis that are based on, and driven by, readily available information about molecular structure. A compilation of successful cocrystallization strategies would offer an invaluable toolbox for incorporating active ingredients (functional molecules) within a crystalline solid that subsequently can provide improved physical properties such as aqueous solubility, mechanical or thermal stability, or reduced hygroscopicity. 

Hexa-/7cn-hexabenzocoronene (HBC), which comprises 13 fused benzene rings, can be regarded as one of the smallest members of molecular graphenes, and has been utilized for supramolecular chemistry aiming at organic electronics. The first synthesis of this important structural motif dates back to the work of Clar and Ironside, where 2 3-7 8-dibenzo-pm-naphthene was allowed to react with Br2 in benzene, and an insoluble fraction, isolated by filtration of the reaction mixture, was heated in a stepwise manner (Scholl reaction. Scheme 1). However, as expected, this solid-state synthesis suffered from low yield and difficulty in purification. Although continuous efforts... 

The application of mechanochemistry in supramolecular synthesis has been extensively used in the past 10 years for obtaining multicomponent molecular crystals in particular in the pharmaceutical field [5, 7]. The production of new solid forms, especially cocrystals is of utmost importance as it provides a way to derivatize active pharmaceutical ingredients (APIs), by modifying their solid-state arrangements rather than their internal molecular structures. Modification of the crystal... 

Especially notable is also the synthesis and structural characterization of an unusual antimony(III) guanidinate. 1,2,3-Tiiisopropylguanidine, Pr N = C(NHPr )2,was found to react with 1 molar equivalent of Sb(NMe2)3 in toluene under formation of a yellow solution, from which the novel compound Sb[Pr NC(NPr )2][Pr NHC(NPr )2] could be isolated in 10% yield as highly air-sensitive crystals. In the solid state, the complex adopts a heavily distorted trigonal-bipyramidal molecular structure in which the Sb is chelated by a [CfNPr ls] dianion and a [Pr NHC(NPr )2] monoanion (Figure 16). Supramolecular... 

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