Solids mixing batch equipment

A standard testing procedure for solids-mixing equipment is available (Ref. 1). This contains details and references pertaining to sampling from solids mixtures for both batch and continuous mixing. 

Several criteria have been used in various studies to judge the performance of dry solids mixing equipment a. the uniformity of the batch with regard to either composition or some other property, b. the time required to achieve a certain uniformity, and c. the power required to mix the batch to a certain degree of uniformity. Most studies have dealt with either a. or b. Complete quantitative performance criteria should cover all three of these aspects. 

A mixer or blender equipped with a heating jacket is preferred a typical starting temperature is about 200 °F (93 °C). The charge includes the suspension resin, stabilizer, and aU nonlubricating solids. Mixing should proceed imtil the batch... 

In batch SPPS (solid-phase peptide synthesis), the resin is contained in a vessel, usually equipped for bottom filtration. After a washing solvent or a reagent is added, the resin is mixed and the solvent or reagent is removed by filtration. Batch synthesizers use a variety of methods to mix the resin the wrist-action shaker, vortex mixing, nitrogen bubbling, or overhead stirring. 

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