Library carbohydrate

P.H. Seeberger, Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries, Wiley, New York, 2004. 

Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries... 

Carbohydrate Libraries in Solution Using Thioglycosides From Multistep Synthesis to Programmable, One-Pot Synthesis... 

Scheme 11.1 Tetrasaccharide yield in a carbohydrate library following limitation of the number of building blocks.

The generality of this strategy was investigated by the preparation of a small carbohydrate library of tri-, tetra-, and pentasaccharides (Table 11.1). This protocol quickly becomes burdensome if libraries (rather than single targets) are desired since it requires isolation of every intermediate. We pursued one-pot methods as a practical and more efficient alternative. (See Scheme 11.11.)... 

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