Solanum alkaloids chemistry

Kusano, G., Takahashi, A., Nozoe, S., Sonoda, Y. and Sato, Y. 1987. Solanum alkaloids as inhibitors of enzymatic conversion of dihydrolanosterol into cholesterol. Chemistry and Pharmacy Bulletin, 35 4321 323. 

This second volume, which reviews the alkaloid literature from July 1970 to June 1971, approaches more closely the standard Specialist Periodical Report originally envisaged by the Chemical Society and adopts a form which, with minor variations, will very probably be followed in subsequent volumes. Once again the whole field of alkaloid chemistry has been reviewed, with the exception of the Steroidal Alkaloids of the Solanum and Veratrum Groups. The omission of these groups in the first volume was deliberate their inclusion in the second volume was intended, but proved to be impracticable, and we hope to remedy this omission in the third volume. It is fortunate, however, that this particular area can quite properly be discussed in a volume devoted to alkaloids or in one devoted to steroids and for a brief review of recent developments in this subject the reader is meanwhile referred to the Specialist Periodical Report on Terpenoids and Steroids, Volume One (Senior Reporter Dr. K. H. Overton). 

The chemistry of the Solanum alkaloids up to the year 1952 has been reviewed fully by V. Prelog and 0. Jeger in Chapter 21 of Volume III of The Alkaloids. More recent work, until about 1957, has been discussed briefly by the same authors in Chapter 16 of Volume VII of this series. The present chapter will deal with work reported since that time results of earlier investigations will be mentioned briefly only if necessary. But the present review will include a tabulated survey of the general occurrence of Solanum alkaloids so far known in the plant kingdom (Table I) and two additional surveys of the well-characterized steroid... 

Keeler, R. R, Young, S., and Brown D. 1976. Spina Bifida, Exencephaly, and Cranial Bleb Produced by the Solanum Alkaloid Solasodine. Research Communications in Chemistry, Pathology and Pharmacology 13 723-730. 

Ripperger, H., and Schreiber, K. 1981. Solanum Steroid Alkaloids. In The Alkaloids-Chemistry and Physiology, Vol.19, Manske, R. H. F., ed. pp.81-192 New York, Academic Press. 

Potato alkaloids. The cultivated potato (Solanum tuberosum L.) contains two major glycoalkaloids, a-chaconine and a-solanine. The two components both contain the C i steroidal aglycone solanidine they differ only in the sugar moieties included in the trisaccharide part. a-Solanine and a-chaconine form up to 95% of the glycoalkaloids present in potatoes. Data on occurrence, chemistry, analysis, and toxicology of the steroidal glycoalkaloids present in potatoes have been comprehensively reviewed (77, 75). 

This survey on steroidal alkaloids of the Veratrum and Solanum family isolated between 1974 and 2014 includes 187 compounds and 197 references. New developments in the chemistry and biology of this family of natural products with a special focus on the medicinal relevance of the jervanine alkaloid cyclopamine are discussed. 

J. Tomko and Z. Voticky in Chapter 1 of Volume 14 (1973). Most recendy, the cevane subgroup of the veratrum alkaloids has been covered by John V. Greenhill and Paul Grayshan in Chapter 4 of Volume 41 (1992). Chapter 4 of the present volume compiles newly isolated alkaloids of the solanum and veratrum groups, their chemistry including recent total syntheses, and their biological properties. 

Wang Y, Kays SJ (2002) Sweetpotato volatile chemistry in relation to sweetpotato weevil (Cylas formicarius) behaviour. J Am Soc Horticult Sci 127 656-662 Wanyonyi AW, Chhabra SC, Mkoji G, Eilert U, Njue WM (2002) Bioactive steroidal alkaloid glycosides from Solanum aculeastrum. Phytochemistry 59 79-84 Wanyonyi AW, Tams PK, Chhabra SC (2003) A novel steroidal alkaloid from Solanum aculeastrum. Bull Chem Soc Ethiopia 17 61-66... 

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